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Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma

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Affiliated Author(s)
이혜원
Alternative Author(s)
Lee, Hye Won
Journal Title
Biomarkers in Medicine
ISSN
1752-0371
Issued Date
2018
Keyword
disease progressionhepatocellular carcinomamicroRNA-21microRNA-31prognosissurvivaltherapeutics
Abstract
Aim:
Aberrant microRNA (miR) expression is associated with hepatocellular carcinoma (HCC).

Materials & methods:
Here, we investigated the clinical significance of miR-21 and miR-31 for HCC-specific prognostic effect. HCC patients (n = 93) who underwent liver biopsy or surgical resection were enrolled, and HCC tissues and paired adjacent nontumor liver tissues were collected and analyzed for miRs expression.

Results:
MiR-21 expression was significantly upregulated in HCC tissues relative to nontumor tissues. Both miR-21 and miR-31 expression in HCC tissues did not predict overall survival; however, miR-21 was considered an independent predictor of disease progression together with portal vein thrombosis and higher Barcelona Clinical Liver Cancer stage.

Conclusion:
Elevated miR-21 expression might represent a biomarker for HCC prognosis.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine (의과대학)
Citation
Jun Sik Yoon et al. (2018). Clinical significance of microRNA-21 expression in disease progression of patients with hepatocellular carcinoma. Biomarkers in Medicine, 12(10), 1105–1114. doi: 10.2217/bmm-2018-0096
Type
Article
ISSN
1752-0371
DOI
10.2217/bmm-2018-0096
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41770
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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