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Implication of ultrasound contrast-enhancement of carotid plaques in prevalence of acute coronary syn drome and occurrence of cardiovascular outcomes

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Affiliated Author(s)
최상웅김형섭김인철이철현황종민박형섭조윤경윤혁준남창욱한성욱허승호
Alternative Author(s)
Kim, Hyung SeopKim, In CheolHwang, Jong MinPark, Hyoung SeobCho, Yun KyeongYoon, Hyuck JunNam, Chang WookHan, Seong WookHur, Seung Ho
Journal Title
Journal of Clinical Ultrasound
ISSN
1097-0096
Issued Date
2018
Keyword
acute coronary syndromecarotid plaquecontrast-enhanced ultrasonography
Abstract
Purpose:
Ultrasonographic contrast enhancement of carotid plaque (CECP) has been used todetect neovascularization of vasa vasorum and plaque. However, it is uncertain whether CECPcan provide risk stratification of coronary artery disease (CAD). This study aimed to evaluate therelationship between CECP and manifestations of acute coronary syndrome (ACS) in establishedCAD patients and to explore the prognostic implication of CECP for cardiovascular (CV) linicaloutcomes.

Methods:
A medical record review revealed that contrast-enhanced ultrasonography was per-formed to evaluate carotid atherosclerosis in 209 coronary artery-stented and 105 non-stentedpatients. The rate of ACS manifestations was compared depending on contrast uptake

patterns:
grade 0, absent; grade 1, dot; and grade 2, diffuse pattern. CV primary outcomes were assessedduring a mean 7.6 months of follow-up.Results: Male sex, smoking, history of old myocardial infarction, intensive medications, and afavorable lipid profile were common in the stented versus non-stented group. Patients withgrade 2 CECP had a higher rate of ACS, greater plaque thickness, and class I-II of Gray-Wealeplaque echogenicity. During follow-up, 10 coronary revascularizations (nine ACSs), six strokes,and four heart failures occurred. Grade 2 CECP was more closely related with CV primary out-comes and showed a tendency toward more acute CV outcomes.

Conclusion:
ACS manifestations were proportionate to CECP grade. Diffuse CECP uptake couldbe a risk factor for acute CV outcomes
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Sang-Woong Choi et al. (2018). Implication of ultrasound contrast-enhancement of carotid plaques in prevalence of acute coronary syn drome and occurrence of cardiovascular outcomes. Journal of Clinical Ultrasound, 46(7), 461–466. doi: 10.1002/jcu.22638
Type
Article
ISSN
1097-0096
DOI
10.1002/jcu.22638
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41798
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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