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Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: A cross-sectional nationwide multicenter study

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Affiliated Author(s)
이주엽박경식
Alternative Author(s)
Lee, Ju YupPark, Kyung Sik
Journal Title
PLoS One
ISSN
1932-6203
Issued Date
2018
Abstract
The aims of this study were to demonstrate the trends in seropositivity and the eradication therapy rate for Helicobacter pylori (H. pylori) over an 18-year period in an asymptomatic Korean population and to explore the factors associated with H. pylori seropositivity and its eradication therapy. In total, 23,770 subjects (aged 17±97 years) from a health examination center participated in this cross-sectional study from January 2016 to June 2017. Questionnaires that included questions about the participants' H. pylori eradication therapy history were collected, and anti-H. pylori IgG antibodies were measured. Among the eligible subjects, the seroprevalence of H. pylori infection was 41.5%. The H. pylori eradication therapy rate increased continuously from 2005 (13.9%) to 2011 (19.3%) and then increased again until the first half of 2017 (23.5%) (P < 0.001). After exclusion of subjects with a history of gastric surgery, gastric cancer, H. pylori eradication therapy, or gastric symptoms, H. pylori seropositivity was 43.9% in 16,885 subjects, which was significantly lower than the seropositivities in 1998 (66.9%), 2005 (59.6%), and 2011 (54.4%). The risk factors associated with H. pylori seropositivity according to multivariable analysis were male sex (odds ratio (OR) 1.34, 95% confidence interval (CI): 1.23±1.46), medium educational level (OR 1.17, 95% CI: 1.05±1.31), medium household income level (OR 1.10, 95% CI: 1.03±1.19), and age of 60±69 years (OR 8.78, 95% CI: 6.41±11.85). The observed downward trend in H. pylori seroprevalence and increase in H. pylori eradication over the 18-year period will affect upper gastrointestinal disorders in South Korea.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Hyun Jin Kim et al. (2018). Trends in the seroprevalence of Helicobacter pylori infection and its putative eradication rate over 18 years in Korea: A cross-sectional nationwide multicenter study. PLoS One, 18(10), e0204762–e0204762. doi: 10.1371/journal.pone.0204762
Type
Article
ISSN
1932-6203
DOI
10.1371/journal.pone.0204762
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41806
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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