계명대학교 의학도서관 Repository

Short-Term Outcome of Ischemic Stroke Patients With Systemic Malignancy

Metadata Downloads
Affiliated Author(s)
유준상
Alternative Author(s)
Yoo, Joon Sang
Journal Title
Stroke
ISSN
1524-4628
Issued Date
2019
Keyword
cancerfollow-up studiesmortalitystroke
Abstract
Background and Purpose
—Recent guidelines have suggested the potential benefit of intravenous thrombolysis in stroke patients with systemic malignancy who have a reasonable life expectancy of >6 months. However, it is difficult to determine which patients with cancer will have a life expectancy of >6 months. Therefore, we identified the factors associated with 6-month mortality in patients with acute ischemic stroke and systemic malignancy.

Methods
—Consecutive stroke patients with systemic malignancy were retrospectively analyzed. We classified the patients into 3 groups: the nonactive cancer, active nonmetastatic cancer, and metastatic cancer groups. We compared the baseline characteristics and 6-month survival rates.

Results
—Of the 468 ischemic stroke patients with systemic malignancy during an 8-year period, 223 patients had nonactive cancer, 105 patients had active nonmetastatic cancer, and 140 patients had metastasis. During the 6-month follow-up, 122 patients (26.1%) died (nonactive cancer group [7.2%, 16/223], active nonmetastatic cancer group [11.4%, 12/105], and metastatic cancer group [67.1%, 94/140]). Multivariate Cox regression analysis revealed that the presence of metastasis (hazard ratio, 4.527; 95% CI, 2.175–9.422) was independently associated with 6-month mortality. However, the active nonmetastatic cancer group exhibited similar 6-month mortality to the nonactive cancer group (hazard ratio, 0.711; 95% CI, 0.282–1.795). Gastric/esophageal cancer and pancreatic cancer were also independently associated with 6-month mortality (hazard ratio, 2.068 and 2.389, respectively).

Conclusions
—In stroke patients with active cancer, the presence of metastasis and the cancer type were crucial factors associated with 6-month mortality.
Department
Dept. of Neurology (신경과학)
Publisher
School of Medicine (의과대학)
Citation
Joonsang Yoo et al. (2019). Short-Term Outcome of Ischemic Stroke Patients With Systemic Malignancy. Stroke, 50(2), 507–511. doi: 10.1161/STROKEAHA.118.023044
Type
Article
ISSN
1524-4628
DOI
10.1161/STROKEAHA.118.023044
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41902
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Neurology (신경과학)
공개 및 라이선스
  • 공개 구분공개
  • 엠바고Forever
파일 목록

Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.