Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population

Authors
Jung Oh KimHyun Woo KimHui Jeong AnOk Joon KimJisu OhSo Young ChongWon‑Il ChoiDoyeun OhNam Keun Kim
Department
Dept. of Internal Medicine (내과학)
Issue Date
2019
Citation
Journal of Thrombosis and Thrombolysis, Vol.47(2) : 255-262, 2019
ISSN
1573-742X
Abstract
Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
Keywords
Deep vein thrombosisMicroRNASingle nucleotide polymorphismPulmonary embolism
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41905
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
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Full Text
https://link.springer.com/article/10.1007%2Fs11239-018-1778-z
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