Association study of miR-146a, miR-149, miR-196a2, and miR-499 polymorphisms with venous thromboembolism in a Korean population
- Affiliated Author(s)
- 최원일
- Alternative Author(s)
- Choi, Won Il
- Journal Title
- Journal of Thrombosis and Thrombolysis
- ISSN
- 1573-742X
- Issued Date
- 2019
- Keyword
- Deep vein thrombosis; MicroRNA; Single nucleotide polymorphism; Pulmonary embolism
- Abstract
- Despite much progress in microRNA (miRNA) research, information regarding the association between miRNAs and venous thromboembolism (VTE), especially in Asian patients, remains limited. This case-control study sought to determine the correlation between the presence of polymorphisms in the genes encoding the miRNAs miR-146a, miR-149, miR-196a2, miR-499, and VTE in Korean patients. We observed no statistically significant differences in the genotype frequency of miRNA polymorphisms between 300 control individuals and 203 VTE patients. However, we observed a significant association between three allelic combinations of miRNA polymorphisms and VTE risk. Overall, our findings suggest that specific miRNA polymorphisms are associated with the risk of VTE in a Korean population.
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