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Rationale, design, and endpoints of the ‘DEvice-Detected Cardiac Tachyarrhythmic Events and Sleep-disordered Breathing (DEDiCATES) study: Prospective multicenter observational study of device-detected tachyarrhythmia and sleep-disordered breathing

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Affiliated Author(s)
박형섭
Alternative Author(s)
Park, Hyoung Seob
Journal Title
International Journal of Cardiology
ISSN
1874-1754
Issued Date
2019
Keyword
Cardiac implantable electronic deviceSleep-disordered breathingObstructive sleep apneaArrhythmia
Abstract
Background:
Few studies have investigated the prognostic value of cardiac implantable electronic device (CIED)- detection of sleep-disordered breathing (SDB) for risk stratification of cardiovascular events. In the Device- Detected CArdiac Tachyarrhythmic events and Sleep-disordered breathing (DEDiCATES) study, we aim to determine whether device-detected SDB events are associated with increased risk of cardiac arrhythmias or other cardiovascular outcomes.

Methods and design:
Six-hundred patients (300 patients with low-voltage pacing devices and 300 with high-voltage defibrillator devices) who have dual chamber CIEDs with AP Scan™ function (Boston Scientific Inc., Marlborough, MA, USA) are planned to be enrolled in this study. AP Scan reports the average number of sleep disturbance events per hour per night in the form of a RespiratoryDisturbance Index(RDI). The dailyRDI values aretobeusedfor quantitativemeasurement of the severity and burden of SDB. CIED-detected atrial high rate episodes (AHREs) and clinical atrial tachyarrhythmia will be assessed as theprimary outcomes over a follow-up period of 2 years. Correlations between CIED-detected SDB and AHRE burdens will be analyzed. The secondary outcomes are CIED-detected or clinical ventricular arrhythmic events, stroke, heart failure hospitalization, mortality, and quality of life.

Conclusion:
This study will determine the prognostic value of automated diagnostic function of CIED for SDB, which will help to improve the cardiovascular prognoses of CIEDpatients by enabling convenient and accurate assessments of SDB events
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Hye Bin Gwag et al. (2019). Rationale, design, and endpoints of the ‘DEvice-Detected Cardiac Tachyarrhythmic Events and Sleep-disordered Breathing (DEDiCATES) study: Prospective multicenter observational study of device-detected tachyarrhythmia and sleep-disordered breathing. International Journal of Cardiology, 280, 69–73. doi: 10.1016/j.ijcard.2019.01.045
Type
Article
ISSN
1874-1754
DOI
10.1016/j.ijcard.2019.01.045
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41913
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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