Is tumor bed boost necessary in patients who achieved ypCR following neoadjuvant chemotherapy and breast conserving therapy? (KROG 12-05 and 16-16)

Authors
Won Kyung ChoWon ParkDoo Ho ChoiYong Bae KimChang-Ok SuhKyung Hwan ShinEui Kyu ChieJin Ho KimSeung Do AhnSu Ssan KimKyubo KimJin Hee KimSung Ja AhnSun Young LeeJeongshim LeeSang-Won KimJeanny KwonKi Jung AhnHyun Soo ShinHyung Sik LeeNam Kwon Lee
Department
Dept. of Radiation Oncology (방사선종양학)
Issue Date
2019
Citation
Breast, Vol.45() : 43-47, 2019
ISSN
1532-3080
Abstract
Purpose: This multi-institutional study intended to investigate the effect of tumor bed boost in patients who achieved pathologic complete response (ypCR) following neoadjuvant chemotherapy (NAC) and breast-conserving therapy (BCT). Materials and methods: We identified 180 patients who initially had lymph node (LN) metastasis and achieved ypCR (ypT0/isN0) following NAC and BCT from the 13 institutions of the Korean Radiation Oncology Group (KROG) 16-16 and KROG 12-05. The effect of tumor bed boost on loco-regional control (LRC), disease-free survival (DFS), and overall survival (OS) rates was analyzed. Results: In all patients, five-year LRC, DFS and OS rates were 97.5%, 95.4%, and 99.4%, respectively. Tumor bed boost was performed in 158 (87.8%) patients. Advanced N-stage (cN2-3, p ¼ 0.036), close resection margin (p < 0.001), and sentinel lymph node biopsy (p ¼ 0.040) were unfavorable factors for DFS. Tumor bed boost was not a significant factor for LRC, DFS, and OS.
Keywords
Breast cancerNeoadjuvant chemotherapyTumor bed boostRadiotherapy
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41951
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학)
Keimyung Author(s)
김진희
Full Text
https://www.clinicalkey.com/#!/content/playContent/1-s2.0-S0960977619300360
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