Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study
- Joo Sung Kim; Jeong Yoon Yim; Suck Chei Choi; Hyun Jin Kim; Joo Hyun Lim; Seon Hee Lim; Nayoung Kim; Jin Won Kwon; Sung Eun Kim; Gwang Ho Baik; Ju Yup Lee; Kyung Sik Park; Jeong Eun Shin; Hyun Joo Song; Dae‑Seong Myung
- Dept. of Internal Medicine (내과학)
- Issue Date
- Digestive Diseases and Sciences, Vol.64(8) : 2219-2230, 2019
- Background and Aim
Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population.
Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria.
After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old.
H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
- Helicobacter pylori; Metabolic syndrome; Cholesterol; Lipid profile
- Appears in Collections:
- 1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
- Keimyung Author(s)
- 이주엽; 박경식
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