Positive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study

Authors
Joo Sung KimJeong Yoon YimSuck Chei ChoiHyun Jin KimJoo Hyun LimSeon Hee LimNayoung KimJin Won KwonSung Eun KimGwang Ho BaikJu Yup LeeKyung Sik ParkJeong Eun ShinHyun Joo SongDae‑Seong Myung
Department
Dept. of Internal Medicine (내과학)
Issue Date
2019
Citation
Digestive Diseases and Sciences, Vol.64(8) : 2219-2230, 2019
ISSN
1573-2568
Abstract
Background and Aim Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.
Keywords
Helicobacter pyloriMetabolic syndromeCholesterolLipid profile
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41954
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
Keimyung Author(s)
이주엽; 박경식
Full Text
https://link.springer.com/article/10.1007%2Fs10620-019-05544-3
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