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dc.contributor.authorJoo Sung Kim-
dc.contributor.authorJeong Yoon Yim-
dc.contributor.authorSuck Chei Choi-
dc.contributor.authorHyun Jin Kim-
dc.contributor.authorJoo Hyun Lim-
dc.contributor.authorSeon Hee Lim-
dc.contributor.authorNayoung Kim-
dc.contributor.authorJin Won Kwon-
dc.contributor.authorSung Eun Kim-
dc.contributor.authorGwang Ho Baik-
dc.contributor.authorJu Yup Lee-
dc.contributor.authorKyung Sik Park-
dc.contributor.authorJeong Eun Shin-
dc.contributor.authorHyun Joo Song-
dc.contributor.authorDae‑Seong Myung-
dc.date.accessioned2019-10-16T16:31:02Z-
dc.date.available2019-10-16T16:31:02Z-
dc.date.issued2019-
dc.identifier.citationDigestive Diseases and Sciences, Vol.64(8) : 2219-2230, 2019-
dc.identifier.issn1573-2568-
dc.identifier.otheroak-2019-0081-
dc.identifier.urihttp://kumel.medlib.dsmc.or.kr/handle/2015.oak/41954-
dc.description.abstractBackground and Aim Helicobacter pylori (H. pylori) infection causes extra-gastrointestinal as well as gastric diseases. This analytical cross-sectional study was performed to investigate the association between H. pylori infection and metabolic syndrome in a Korean population. Methods Anthropometric and metabolic data, as well as anti-H. pylori IgG antibodies, were measured in 21,106 subjects who participated in a health checkup between January 2016 and June 2017. The classification of metabolic syndrome followed the revised National Cholesterol Education Program criteria. Results After excluding subjects with a history of H. pylori eradication therapy, or gastric symptoms, the seropositivity of H. pylori was 43.2% in 15,195 subjects. H. pylori-positive participants had significantly higher body mass index (BMI), waist circumference, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and lower high-density lipoprotein (HDL-C) than did seronegative participants (P < 0.05). After adjusting for confounders, high TC, low HDL-C, and high LDL-C were associated with H. pylori seropositivity. Finally, the prevalence of metabolic syndrome was higher in H. pylori-seropositive subjects than in negative ones (27.2% vs. 21.0%, P < 0.05), and H. pylori seropositivity increased the likelihood of metabolic syndrome (OR 1.19, 95% CI 1.09–1.31, P < 0.001) after adjusting for sex, age, BMI, smoking, residence, household income, and education level. However, the association between H. pylori seropositivity and metabolic syndrome disappeared in those ≥ 65 years old. Conclusions H. pylori infection plays an independent role in the pathogenesis of metabolic syndrome in Koreans under 65 years old.-
dc.description.statementofresponsibilityprohibition-
dc.publisherSchool of Medicine (의과대학)-
dc.rightsBY_NC_ND-
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/2.0/kr-
dc.subjectHelicobacter pylori-
dc.subjectMetabolic syndrome-
dc.subjectCholesterol-
dc.subjectLipid profile-
dc.titlePositive Association Between Helicobacter pylori Infection and Metabolic Syndrome in a Korean Population: A Multicenter Nationwide Study-
dc.typeArticle-
dc.contributor.localauthor이주엽-
dc.contributor.localauthor박경식-
dc.contributor.alternativelocalauthorLee, Ju Yup-
dc.contributor.alternativelocalauthorPark, Kyung Sik-
dc.contributor.departmentDept. of Internal Medicine (내과학)-
dc.citation.volume64-
dc.citation.number8-
dc.citation.startpage2219-
dc.citation.titleDigestive Diseases and Sciences-
dc.citation.endpage2230-
dc.identifier.doi10.1007/s10620-019-05544-3-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs10620-019-05544-3-


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