Genetic features associated with 18F-FDG uptake in intrahepatic cholangiocarcinoma

Authors
Keun Soo AhnKoo Jeong KangYong Hoon KimTae-Seok KimBong-Il SongHae Won KimDaniel O’BrienLewis R. RobertsJeong Woo LeeKyoung Sook Won
Department
Dept. of Surgery (외과학); Dept. of Nuclear Medicine (핵의학)
Issue Date
2019
Citation
Annals of Surgical Treatment and Research, Vol.96(4) : 153-161, 2019
ISSN
2288-6796
Abstract
Purpose: In intrahepatic cholangiocarcinoma (iCCA), genetic characteristics on 18F-fluorodeoxyglucose (18F-FDG)-PET scans are not yet clarified. If specific genetic characteristics were found to be related to FDG uptake in iCCA, we can predict molecular features based on the FDG uptake patterns and to distinguish different types of treatments. In this purpose, we analyzed RNA sequencing in iCCA patients to evaluate gene expression signatures associated with FDG uptake patterns. Methods: We performed RNA sequencing of 22 cases iCCA who underwent preoperative 18F-FDG-PET, and analyzed the clinical and molecular features according to the maximum standard uptake value (SUVmax). Genes and biological pathway which are associated with SUVmax were analyzed. Results: Patients with SUVmax higher than 9.0 (n = 9) had poorer disease-free survival than those with lower SUVmax (n = 13, P = 0.035). Genes related to glycolysis and gluconeogenesis, phosphorylation and cell cycle were significantly correlated with SUVmax (r ≥ 0.5). RRM2, which is related to the toxicity of Gemcitabine was positively correlated with SUVmax, and SLC27A2 which is associated with Cisplastin response was negatively correlated with SUVmax. According to the pathway analysis, cell cycle, cell division, hypoxia, inflammatory, and metabolism-related pathways were enriched in high SUVmax patients. Conclusion: The genomic features of gene expression and pathways can be predicted by FDG uptake features in iCCA. Patients with high FDG uptake have enriched cell cycle, metabolism and hypoxic pathways, which may lead to a more rational targeted treatment approach.
Keywords
CholangiocarcinomaFluorodeoxyglucose F18Positron-emission tomographyGene expressionCell cycle
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41974
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
Keimyung Author(s)
안근수; 강구정; 김용훈; 김태석; 송봉일; 김해원; 원경숙
Full Text
https://www.astr.or.kr/DOIx.php?id=10.4174/astr.2019.96.4.153
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