Prognostic impact of telomeric repeat-containing RNA expression on long-term oncologic outcomes in colorectal cancer

Authors
Sung Uk BaeWon-Jin ParkWoon Kyung JeongSeong Kyu BaekHye-Won LeeJae-Ho Lee
Department
Dept. of Surgery (외과학); Dept. of Pathology (병리학); Dept. of Anatomy (해부학)
Issue Date
2019
Citation
Medicine, Vol.98(14) : -, 2019
ISSN
1536-5964
Abstract
Telomeres are transcribed into long, noncoding telomeric repeat-containing RNAs (TERRA) that have been implicated in the regulation of telomerase, the enzyme that lengthens telomeres, in heterochromatin formation at telomeres, and in telomere stability. This study aimed to evaluate the correlation between TERRA expression and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated 18p TERRA expression and telomere length using quantitative real-time PCR in 60 patients who underwent surgical resection for CRC between June 2008 and November 2010. Patients were grouped according to 18p TERRA expression, with 29 (48.3%) and 31 (51.7%) patients in the low and high TERRA expression groups, respectively. The median follow-up period was 80 months (range 2–103). The 18p TERRA expression was marginally significantly associated with preoperative carcinoembryonic antigen (CEA; P=.082) and was significantly associated with telomere length (P<.05). Multivariate analysis revealed that preoperative CEA (hazard ratio [HR], 2.728; 95% confidence interval [CI], 0.832–8.944, P=.098) and 18p TERRA expression (HR, 0.113; 95% CI, 0.011–1.126, P=.071) were marginally significant independent prognostic factors for overall survival (OS), whereas preoperative CEA (HR, 4.254; 95% CI, 1.394–12.985, P=.011) and 18p TERRA expression (HR, 0.108; 95% CI, 0.011–1.037, P=.054) were significant independent prognostic factors for disease-free survival (DFS). According to our prognostic model with 2 prognostic factors, the OS and DFS rate increased to 76.2% and 80.63%, respectively, in patients with high 18p TERRA expression and CEA levels 5 (P=.178, P=.057, respectively). 18p TERRA expression was marginally significantly associated with preoperative CEA and significantly associated with telomere length, rendering it a potential prognostic factor for long-term oncologic outcomes in CRC.
Keywords
colonic neoplasmslong noncodingprognosisRNAtelomeretelomere homeostasis
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/41977
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
Keimyung Author(s)
배성욱; 정운경; 백성규; 이혜원; 이재호
Full Text
https://insights.ovid.com/pubmed?pmid=30946316
File in this Item
oak-2019-0104.pdf(583.15 kB)Download
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE