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Clinical and Prognostic Value of Human Mammary Tumor Virus in Korean Patients with Breast Carcinoma

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Affiliated Author(s)
조지형이무현권선영이재호
Alternative Author(s)
Cho, Ji HyoungLee, Moo HyunKwon, Sun YoungLee, Jae Ho
Journal Title
Annals of clinical and laboratory science
ISSN
1550-8080
Issued Date
2019
Keyword
Breast cancerHuman mammary tumor virusMouse mammary tumor virus
Abstract
BACKGROUND:
Human mammary tumor virus (HMTV) is 90-95% homologous to mouse mammary tumor virus, one of the causal agents of murine mammary tumors. Although HMTV has been frequently detected in human breast cancers, its clinical and prognostic value remains unknown.

METHODS:
In the present study, we analyzed HMTV infection using polymerase chain reaction (PCR) in 128 breast cancers.

RESULTS:
HMTV was found in 9.4% (12/128) of breast cancers and was significantly associated with breast pain (66.7% vs. 11.7%, p=0.007). It had a tendency to be detected more frequently in breast cancer patients with lower BMI<25, although this result was not statistically significant (18.8% vs. 5.4%, p=0.103). Kaplan-Meier survival analysis showed no prognostic value of HMTV in breast cancer (χ2=0.148, p=0.700). For the first time, we investigated the clinical and prognostic value of HMTV in Korean patients with breast cancer.

CONCLUSION:
Although our study revealed that HMTV infection does not have important clinical significance in breast cancer, the possibility remains that it may be a prominent causative agent of the disease.
Department
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Incheol Seo et al. (2019). Clinical and Prognostic Value of Human Mammary Tumor Virus in Korean Patients with Breast Carcinoma. Annals of clinical and laboratory science, 49(2), 171–174.
Type
Article
ISSN
1550-8080
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/41997
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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