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The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open- Label, Single-Center Phase 2 Trial

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Affiliated Author(s)
이무현
Alternative Author(s)
Lee, Moo Hyun
Journal Title
Annals of Surgical Oncology
ISSN
1534-4681
Issued Date
2019
Abstract
Background.
This study aimed to compare the sentinel lymph node (SLN) identification rates for breast cancer patients after neoadjuvant chemotherapy (NAC) between the dual method (DM) of indocyanine green fluorescence (ICG-F) plus a radioisotope (RI) and RI alone.

Methods.
This randomized study enrolled 130 patients who received NAC for breast cancer and 122 patients who received SLN biopsy (SLNB) using either DM (n = 58) or RI only (n = 64). The study compared the identification rate, number of SLNs, and detection time of SLNB.

Results.
Among the 122 patients, 113 (92.6%) were clinically node-positive before NAC. The SLN identification rate was 98.3% in the DM group and 93.8% in the RI group (p = 0.14). The DM group and the RI group were similar in the average number of SLNs (2.2 ± 1.13 vs. 1.9 ± 1.33; p = 0.26) and the time to detection of the first SLN (8.7 ± 4.98 vs. 8.3 ± 4.31 min; p = 0.30). In the DM group, transcutaneous lymphatic drainage was visualized by fluorescence imaging for 65.5% (38 of 58) of the patients. The SLN identification rate was 94.7% using ICGF and 93% using RI (p = 0.79). During and after the operation, no complications, including allergic reactions or skin necrosis, occurred.

Conclusions.
This study is the first randomized trial to use ICG-F for SLNB in breast cancer patients after NAC. The DM including ICG-F could be a feasible and safe method for SLNB in initially node-positive breast cancer patients with NAC.
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Han-Sung Kang et al. (2019). The Sentinel Lymph Node Biopsy Using Indocyanine Green Fluorescence Plus Radioisotope Method Compared With the Radioisotope-Only Method for Breast Cancer Patients After Neoadjuvant Chemotherapy: A Prospective, Randomized, Open- Label, Single-Center Phase 2 Trial. Annals of Surgical Oncology, 26(8), 2409–2416. doi: 10.1245/s10434-019-07400-0
Type
Article
ISSN
1534-4681
DOI
10.1245/s10434-019-07400-0
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42004
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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