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Course of upper eyelid retraction in thyroid eye disease

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Affiliated Author(s)
이동철
Alternative Author(s)
Lee, Dong Cheol
Journal Title
Br J Ophthalmol
ISSN
1468-2079
Issued Date
2019
Abstract
Aims
To evaluate the natural course of upper eyelid retraction (UER) in patients with thyroid eye disease (TED) and factors affecting its course.

Methods
Retrospective non-interventional cohort study in a single tertiary institution from March 2006 to March 2015 on patients with TED with (1) unilateral or bilateral UER within 6 months from initial presentation, and (2) no prior interventions nor surgical treatment for their UER. Main outcomes and measures were mean margin reflex distance 1 (MRD1) and factors associated with UER improvement.

Results
There were a total of 61 patients and 81 eyes (41 unilateral and 20 bilateral UER). Mean age was 42.3±15.1 years. Mean MRD1 decreased from 6.1 mm at presentation to 4.8 mm at 12 months, and 4.4 mm at 24 months. The proportion of eyes with normalisation of lid height increased from 0% at presentation to 22.2% at 6 months, 37.0% at 12 months and 49.4% at 24 months. Mean time to normalisation of MRD1 was 18.0±12.4 months. A positive family history of TED was found to be associated with a 6.2 times lower likelihood of normalisation. Change in exophthalmometry, clinical activity score and thyroid-stimulating immunoglobulin were significantly correlated to change in MRD1 (p<0.05). There was no correlation between change in MRD1 and thyroid-stimulating hormone receptor antibodies.

Conclusion
An improved knowledge of the natural history of UER in TED will allow us to better decide and evaluate the optimal management for such patients.
Department
Dept. of Ophthalmology (안과학)
Publisher
School of Medicine (의과대학)
Citation
Dong Cheol Lee et al. (2019). Course of upper eyelid retraction in thyroid eye disease. Br J Ophthalmol. doi: 10.1136/bjophthalmol-2018-313578
Type
Article
ISSN
1468-2079
DOI
10.1136/bjophthalmol-2018-313578
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42006
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Ophthalmology (안과학)
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