Long-Term Comparison of Platinum Chromium Everolimus-Eluting Stent vs. Cobalt Chromium Zotarolimus-Eluting Stent ― 3-Year Outcomes From the HOST–ASSURE Randomized Clinical Trial ―

Authors
Chee Hae KimKyung Woo ParkJeehoon KangByoung-Eun ParkKwang Soo ChaJay Young RhewHui-Kyung JeonEun-Seok ShinJu Hyeon OhMyung-Ho JeongSanghyun KimKyung-Kuk HwangJung-Han YoonSung Yun LeeTae-Ho ParkKeon Woong MoonHyuck-Moon KwonSeung-Ho HurJae-Kean RyuBong-Ryul LeeYong Whi ParkIn-Ho ChaeHyo-Soo Kim
Department
Dept. of Internal Medicine (내과학)
Issue Date
2019
Citation
Circulation Journal, Vol.83(7) : 1489-1497, 2019
ISSN
1347-4820
Abstract
Background: There are limited data on the long-term outcome of platinum chromium-based everolimus-eluting stents (PtCr-EES) vs. cobalt chromium-based zotarolimus-eluting stents (CoCr-ZES). Methods and Results; A total of 3,755 patients undergoing percutaneous coronary intervention (PCI) were randomized 2:1 to PtCr- EES or CoCr-ZES, and 96.0% of patients completed the 3-year clinical follow-up. The primary outcome was target lesion failure (TLF), defined as a composite of cardiac death, target vessel-related myocardial infarction (MI), and clinically-driven target lesion revascularization (TLR). At 3 years, TLF occurred in 5.3% and in 5.4% of the PtCr-EES and CoCr-ZES groups, respectively (hazard ratio 0.978; 95% confidence interval 0.730–1.310, P=0.919). There were no significant differences in the individual components of TLF. Routine angiographic follow-up was performed in 38.9% of the total patients. In a landmark analysis of the subgroup that had follow-up angiography, the clinically-driven TLR rate of CoCr-ZES was significantly higher than PtCr-EES group during the angiography follow-up period (P=0.009). Overall definite and probable stent thrombosis rates were very low in both groups (0.5% vs. 0.6%, P=0.677). Conclusions: PtCr-EES and CoCr-ZES had similar and excellent long-term outcomes in both efficacy and safety after PCI in an all-comer population.
Keywords
Clinical outcomeCobalt chromium-based zotarolimus-eluting stentDrug-eluting stentPercutaneous coronary interventionPlatinum chromium-based everolimus-eluting stent
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42023
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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Full Text
https://www.jstage.jst.go.jp/article/circj/83/7/83_CJ-18-1303/_article
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