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Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells

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Affiliated Author(s)
권택규
Alternative Author(s)
Kwon, Taeg Kyu
Journal Title
Archives of Pharmacal Research
ISSN
1976-3786
Issued Date
2019
Keyword
TRAILDeath receptorExpressionLocalizationApoptosis
Abstract
The tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induces apoptosis via death receptor (DR) 4 or DR5 preferentially in cancer cells, and not in normal cells with relatively high decoy receptor expression. However, multiple mechanisms in cancer cells induce resistance to DRs-mediated apoptosis. Therefore, understanding of molecular mechanisms for resistance to DRs-mediated apoptosis can find the strategy to increase sensitivity. Although multiple proteins are involved in resistance to DRs-mediated apoptosis, we focus on modulation of DR5 to overcome resistance. Here, we discuss regulation of DR5 expression or activation by epigenetic modification, transcription factor at the transcriptional levels, micro RNA and RNA-binding proteins at the post-transcriptional levels, and ubiquitination and glycosylation at the post-translational levels. In addition, we also mention about relationship between localization of DR5 and death signaling activation. The purpose of this review is to help understand relationship between regulatory mechanisms of DR5 and resistance to TRAIL or DRs-targeted agonist monoclonal antibodies, and to develop innovative anti-cancer therapies through regulation of DR5 signaling.
Department
Dept. of Immunology (면역학)
Publisher
School of Medicine (의과대학)
Citation
Kyoung-jin Min et al. (2019). Elucidation for modulation of death receptor (DR) 5 to strengthen apoptotic signals in cancer cells. Archives of Pharmacal Research, 42(1), 88–100. doi: 10.1007/s12272-018-01103-y
Type
Article
ISSN
1976-3786
DOI
10.1007/s12272-018-01103-y
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42139
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
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