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Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer

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Affiliated Author(s)
황일선강선희권선영
Alternative Author(s)
Hwang, Il SeonKang, Sun HeeKwon, Sun Young
Journal Title
Journal of Breast Cancer
ISSN
2092-9900
Issued Date
2019
Keyword
Breast neoplasmsCD11c antigenCD163 antigenCD68 antigenMacrophages
Abstract
Purpose:
Tumor-associated macrophages (TAMs) are activated macrophages associated with tumor progression in various cancers. TAMs can polarize M1 or M2 type. M1 has a pro-inflammatory function and kills pathogens. Conversely, M2 shows immunosuppressive action and promotes tumor growth. There are various markers of TAMs. CD11c is considered as a specific marker of M1. CD163 is an optimal marker for M2. CD68 is known as a pan-macrophage marker. We evaluated the relationship between the clinicopathological parameters and immunohistochemical expressions of CD11c, CD163, and CD68 in invasive breast cancer (IBC), and the prognostic value of macrophage localization within the tumor stroma (TS) and tumor nest (TN).

Methods:
Immunohistochemistry of CD68, CD11c, and CD163 was analyzed on tissue microarrays of 367 IBCs. The number of CD68+, CD11c+, or CD163+ macrophages in TN vs. TS was counted by 2 pathologists. The correlations between the degree of macrophage (CD68+, CD11c+, or CD163+) infiltration and the clinicopathological parameters were analyzed. We also assessed the impact of macrophages (CD68+, CD11c+, or CD163+) on disease free survival (DFS) and overall survival (OS).

Results:
High numbers of macrophages (CD68+, CD11c+, or CD163+) were associated with higher histologic grade, higher Ki-67 proliferating index, estrogen receptor negativity, and progesterone receptor negativity. High numbers of macrophages (CD11c+ or CD163+) in TS were associated with a larger tumor size. Furthermore, CD163+ macrophages in TN were an independent prognostic marker of reduced OS and DFS. Conversely, CD11c+ macrophages in TS were an independent prognostic marker for higher OS and DFS.

Conclusion:
TAMs, including M2 type, are associated with tumor progression in IBC. They can also act as a significant unfavorable or favorable prognostic factor. In addition to simply analyzing the degree of TAM infiltration, it is also important to analyze the location of TAMs.
Department
Dept. of Pathology (병리학)
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Hasong Jeong et al. (2019). Tumor-Associated Macrophages as Potential Prognostic Biomarkers of Invasive Breast Cancer. Journal of Breast Cancer, 22(1), 38–51. doi: 10.4048/jbc.2019.22.e5
Type
Article
ISSN
2092-9900
DOI
10.4048/jbc.2019.22.e5
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42160
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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