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Correlation between Cytokine and Chemokine levels and Clinical Severity in Children with Mycoplasma pneumoniae Pneumonia

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Affiliated Author(s)
최희정
Alternative Author(s)
Choi, Hee Joung
Journal Title
Pediatric Infection and Vaccine
ISSN
2384-1087
Issued Date
2019
Keyword
Mycoplasma pneumoniaePneumoniaChildrenCytokinesChemokines
Abstract
Purpose:
The aim of this study was to evaluate the relationships between cytokine and chemokine levels and the clinical severity of Mycoplasma pneumoniae pneumonia.

Methods:
A retrospective analysis of clinical and laboratory parameters were performed. Serum levels of interleukin (IL)-6, IL-8, IL-10, IL-18, interferon-γ-inducible protein-10 (IP-10), macrophage inflammatory protein-1β, and tumor necrosis factor-α were measured. The severity of patients' clinical course and radiologic findings were also assessed.

Results:
Seventy-two patients (35 males and 37 females) with a median age of 3.9 years (range, 1–16 years) were enrolled. Patients with lobar pneumonia (n=29) had significantly higher C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), and IL-18 values than those with broncho-interstitial pneumonia (n=43). However, the cytokine and chemokine values did not differ between the group that was treated with corticosteroids (n=31) and the one that was not (n=41). The CRP, ESR, lactate dehydrogenase (LDH), IL-18, and IP-10 values showed positive correlations with fever duration prior to admission. The CRP and ESR values were positively correlated with IL-18, and LDH, with IP-10 levels.

Conclusions:
CRP, ESR, LDH, IL-18, and IP-10 values were associated with the severity of the disease, manifesting lobar pneumonia or prolonged fever duration prior to admission.
Department
Dept. of Pediatrics (소아청소년학)
Publisher
School of Medicine (의과대학)
Citation
Hee Joung Choi. (2019). Correlation between Cytokine and Chemokine levels and Clinical Severity in Children with Mycoplasma pneumoniae Pneumonia. Pediatric Infection and Vaccine, 26(1), 51–59. doi: 10.14776/piv.2019.26.e6
Type
Article
ISSN
2384-1087
DOI
10.14776/piv.2019.26.e6
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42168
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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