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Outcomes of Pregnancy After Breast Cancer in Korean Women: A Large Cohort Study

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Affiliated Author(s)
이무현
Alternative Author(s)
Lee, Moo Hyun
Journal Title
Cancer Research and Treatment
ISSN
2005-9256
Issued Date
2019
Keyword
Breast neoplasmsCancer survivorsPregnancy
Abstract
Purpose:
The purpose of this study was to determine the rate and outcomes of pregnancies subsequent to breast cancer in Korea, and the effect of such pregnancies on the prognosis of women who survived breast cancer and subsequently conceived.

Materials and methods:
We followed a total of 31,761 Korean women 45 years of age or younger who were treated for primary breast cancer from 2002 to 2010. We also included follow-up surveys that were conducted through December 2011. We identified recurrence and mortality from breast cancer using data linked to the Korea National Health Insurance database. We used propensity score matching of the study cohort to analyze the risks of recurrence and mortality from breast cancer depending on pregnancy.

Results:
Within our sample, 992 women (3.1%) became pregnant after receiving treatment for breast cancer. Of those, 622 (67.5%) successfully delivered; the remaining 370 (32.5%) failed to deliver. After propensity score matching, we found that the women who became pregnant after breast cancer did not have a different risk of recurrence (hazard ratio [HR], 0.503; 95% confidence interval [CI], 0.434 to 0.584) and death (HR, 0.520; 95% CI, 0.397 to 0.681), compared with those who did not conceive after breast cancer treatment.

Conclusion:
Our study is the first to report outcomes for Korean women who survived breast cancer and subsequently conceived. Women who survived breast cancer and subsequently became pregnant did not show a poorer survival outcome, compared with those who did not become pregnant.
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Moo Hyun Lee et al. (2019). Outcomes of Pregnancy After Breast Cancer in Korean Women: A Large Cohort Study. Cancer Research and Treatment. doi: 10.4143/crt.2018.382
Type
Article
ISSN
2005-9256
DOI
10.4143/crt.2018.382
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42325
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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