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Prominent Seasonal Variation in Pulmonary Embolism Than Deep Vein Thrombosis Incidence: A Korean Venous Thrombosis Epidemiology Study

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Affiliated Author(s)
최원일
Alternative Author(s)
Choi, Won Il
Journal Title
Korean journal of internal medicine
ISSN
2005-6648
Issued Date
2019
Keyword
SeasonsEpidemiologyVenous thromboembolismPulmonary embolismDeep vein thrombosis
Abstract
Background/Aims:
Seasonal variation is an environmental factor proposed to affect the incidence of venous thromboembolism (VTE). However, VTE seasonal variation is not well studied in Asian populations, which have different genetic determinants of VTE compared to Westerners. The present study aimed at investigating seasonal variation of VTE occurrence and the effect of various demographic factors (i.e., age, sex, and co-morbidities) on variation.

Methods:
VTE seasonal variation was evaluated in 59,626 index cases (from January 2009 to December 2013) in the Korean Health Insurance Review and Assessment Service database. We quantified and compared VTE occurrence across four seasons, and additionally assessed monthly through a chronobiological analysis.

Results:
VTE incidence varied both seasonally and monthly, with new cases peaking in the winter (January and February) and the lowest incidence in the summer (August and September). After adjusting for sex, age, type of VTE, and combined cancer diagnosis, winter remained a significant independent factor driving VTE incidence. Additionally, seasonal variation was prominent in patients aged 60 years or older and in patients with pulmonary embolism, but not so prominent in patients of aged less than 60 years and patients with deep vein thrombosis.

Conclusions:
Seasonal variation was a weak but independent contributor to VTE incidence in a Korean population diagnosed from 2009 to 2013, especially in those individuals with old age or suffering from a pulmonary embolism.
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Junshik Hong et al. (2019). Prominent Seasonal Variation in Pulmonary Embolism Than Deep Vein Thrombosis Incidence: A Korean Venous Thrombosis Epidemiology Study. Korean journal of internal medicine. doi: 10.3904/kjim.2018.370
Type
Article
ISSN
2005-6648
DOI
10.3904/kjim.2018.370
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42385
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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