Effect of Low-Dose Nebivolol in Patients with Acute Myocardial Infarction: A Multi-Center Observational Study

Authors
Doo Sun SimDae Young HyunMyung Ho JeongHyo Soo KimKiyuk ChangDong Ju ChoiKyoo Rok Han5Tae Hoon AhnJang Hwan BaeSi Wan ChoiJong Seon ParkSeung Ho HurJei Keon ChaeSeok Kyu OhKwang Soo ChaJin Yong Hwang
Department
Dept. of Internal Medicine (내과학)
Issue Date
2020
Citation
Chonnam Medical Journal, Vol.56(1) : 55-61, 2020
ISSN
2233-7393
Abstract
The optimal dose of beta blockers after acute myocardial infarction (MI) remains uncertain. We evaluated the effectiveness of low-dose nebivolol, a beta1 blocker and a vasodilator, in patients with acute MI. A total of 625 patients with acute MI from 14 teaching hospitals in Korea were divided into 2 groups according to the dose of nebivolol (nebistol®, Elyson Pharmaceutical Co., Ltd., Seoul, Korea): low-dose group (1.25 mg daily, n=219) and usual- to high-dose group (≥2.5 mg daily, n=406). The primary endpoints were major adverse cardiac and cerebrovascular events (MACCE, composite of death from any cause, non-fatal MI, stroke, repeat revascularization, rehospitalization for unstable angina or heart failure) at 12 months. After adjustment using inverse probability of treatment weighting, the rates of MACCE were not different between the low-dose and the usual- to high-dose groups (2.8% and 3.1%, respectively; hazard ratio: 0.92, 95% confidence interval: 0.38 to 2.24, p=0.860). The low-dose nebivolol group showed higher rates of MI than the usual- to high-dose group (1.2% and 0%, p=0.008). The 2 groups had similar rates of death from any cause (1.1% and 0.3%, p=0.273), stroke (0.4% and 1.1%, p=0.384), repeat PCI (1.2% and 0.8%, p=0.428), rehospitalization for unstable angina (1.2% and 1.0%, p=0.743) and for heart failure (0.6% and 0.7%, p=0.832). In patients with acute MI, the rates of MACCE for low-dose and usual- to high-dose nebivolol were not significantly different at 12-month follow-up.
Keywords
Beta-Adrenergic ReceptorsHeart FailureHypertensionMyocardial Infarction
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42543
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
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Full Text
https://cmj.ac.kr/DOIx.php?id=10.4068/cmj.2020.56.1.55
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