Factors associated with Advanced Bone Age in Overweight and Obese Children

Authors
Min-Su OhSorina KimJuyeon LeeMu Sook LeeYoon-Joo KimKi-Soo Kang
Department
Dept. of Radiology (영상의학)
Issue Date
2020
Citation
Pediatric Gastroenterology, Hepatology & Nutrition, Vol.23(1) : 89-97, 2020
ISSN
2234-8840
Abstract
Purpose: Obese children may often present with advanced bone age. We aimed to evaluate the correlation between factors associated with childhood obesity and advanced bone age. Methods: We enrolled 232 overweight or obese children. Anthropometric and laboratory data, and the degree of nonalcoholic fatty liver disease (NAFLD) were measured. We analyzed factors associated with advanced bone age by measuring the differences between bone and chronological ages. Results: The normal and advanced bone age groups were comprised of 183 (78.9%) and 49 (21.1%) children, respectively. The prevalence of advanced bone age significantly increased as the percentiles of height, weight, waist circumference, and body mass index (BMI) increased. BMI z-score was higher in the advanced bone age group than in the normal bone age group (2.43±0.52 vs. 2.10±0.46; p<0.001). The levels of insulin (27.80±26.13 μU/mL vs. 18.65±12.33 μU/mL; p=0.034) and homeostatic model assessment–insulin resistance (6.56±6.18 vs. 4.43±2.93; p=0.037) were significantly higher, while high density lipoprotein-cholesterol levels were lower (43.88±9.98 mg/dL vs. 48.95±10.50 mg/dL; p=0.005) in the advanced bone age group compared to those in the normal bone age group, respectively. The prevalence of advanced bone age was higher in obese children with metabolic syndrome than in those without (28.2% vs. 14.7%; p=0.016). The prevalence of advanced bone age was higher in obese children with a more severe degree of NAFLD. Conclusion: Advanced bone age is associated with a severe degree of obesity and its complications.
Keywords
ObesityChildrenBone ageMetabolic syndromeNonalcoholic fatty liver disease
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42556
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Radiology (영상의학)
Keimyung Author(s)
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Full Text
https://www.pghn.org/search.php?where=aview&id=10.5223/pghn.2020.23.1.89&code=1121PGHN&vmode=FULL
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