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Cardiac CT for Measurement of Right Ventricular Volume and Function in Comparison with Cardiac MRI: A Meta-Analysis

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Author(s)
Jin Young KimYoung Joo SuhKyunghwa HanYoung Jin KimByoung Wook Choi
Publication Year
2020
Keyword
Right ventricular functionVolumetryComputed tomographyMagnetic resonance imagingMeta-analysis
Abstract
Objective:
We performed a meta-analysis to evaluate the agreement of cardiac computed tomography (CT) with cardiac magnetic resonance imaging (CMRI) in the assessment of right ventricle (RV) volume and functional parameters.

Materials and Methods:
PubMed, EMBASE, and Cochrane library were systematically searched for studies that compared CT with CMRI as the reference standard for measurement of the following RV parameters: end-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), or ejection fraction (EF). Meta-analytic methods were utilized to determine the pooled weighted bias, limits of agreement (LOA), and correlation coefficient (r) between CT and CMRI. Heterogeneity was also assessed. Subgroup analyses were performed based on the probable factors affecting measurement of RV volume: CT contrast protocol, number of CT slices, CT reconstruction interval, CT volumetry, and segmentation methods.

Results:
A total of 766 patients from 20 studies were included. Pooled bias and LOA were 3.1 mL (−5.7 to 11.8 mL), 3.6 mL (−4.0 to 11.2 mL), −0.4 mL (5.7 to 5.0 mL), and −1.8% (−5.7 to 2.2%) for EDV, ESV, SV, and EF, respectively. Pooled correlation coefficients were very strong for the RV parameters (r = 0.87–0.93). Heterogeneity was observed in the studies (I2 > 50%, p < 0.1). In the subgroup analysis, an RV-dedicated contrast protocol, ≥ 64 CT slices, CT volumetry with the Simpson's method, and inclusion of the papillary muscle and trabeculation had a lower pooled bias and narrower LOA.

Conclusion:
Cardiac CT accurately measures RV volume and function, with an acceptable range of bias and LOA and strong correlation with CMRI findings. The RV-dedicated CT contrast protocol, ≥ 64 CT slices, and use of the same CT volumetry method as CMRI can improve agreement with CMRI.
Alternative Title
Cardiac CT for Measurement of Right Ventricular Volume and Function in Comparison with Cardiac MRI: A Meta-Analysis
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Korean Journal of Radiology, Vol.21(4) : 450-461, 2020
Type
Article
ISSN
2005-8330
DOI
10.3348/kjr.2019.0499
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42689
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