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Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry

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Author(s)
조윤경박형섭윤혁준김형섭한성욱허승호김윤년김권배남창욱
Alternative Author(s)
Kim, Kwon BaeKim, Yoon NyunCho, Yun KyeongPark, Hyoung SeobYoon, Hyuck JunKim, Hyung SeopHan, Seong WookHur, Seung Ho
Publication Year
2020
Keyword
DyslipidemiasCholesterolHydroxymethylglutaryl-CoA reductase inhibitors
Abstract
Background/Aims:
To date, prospective data are limited on efficacy and safety profiles of statin therapy in Korean hypercholesterolemic patients. Hence, the aim of this study was to evaluate the practice patterns of statin therapy and its efficacy and safety through the prospective Daegu and Gyeongbuk statin registry.

Methods:
Statin naïve patients who were prescribed statins according to the criteria of Korean Guidelines for Management of Dyslipidemia were enrolled. Clinical and laboratory evaluations were performed at baseline and at week 8, where the efficacy was assessed with the same guidelines.

Results:
Of 908 patients, atorvastatin and rosuvastatin were most frequently prescribed statins (63.1% and 29.3%, respectively). High intensity statins (atorvastatin 40 mg or rosuvastatin 20 mg) were prescribed in 24.7% of all patients and in 79.5% of high and very high risk groups. The total and low density lipoprotein (LDL) cholesterol levels decreased from 203.7 ± 43.0 to 140.6 ± 28.6 mg/dL and 134.4 ± 35.7 to 79.5 ± 21.3 mg/dL, respectively. The achievement rate of the LDL target goal was 98.6% in low risk, 95.0% in moderate risk, 88.1% in high risk, and 42.1% in very high risk patients (59.7% in overall). There was no significant difference in the efficacy between atorvastatin and rosuvastatin. Adverse events were observed in 12.0% of patients and led to 1.4% of treatment cessation.

Conclusions:
The efficacy of the usual starting dose of statins in daily practice was relatively insufficient for Korean hypercholesterolemic patients with high or very high risks. Short-term adverse events of statin therapy were not common in Korean patients with a low discontinuation rate.
Alternative Title
Early efficacy and safety of statin therapy in Korean patients with hypercholesterolemia: Daegu and Gyeongbuk Statin Registry
Department
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
The Korean Journal of Internal Medicine, Vol.35(2) : 342-350, 2020
Type
Article
ISSN
2005-6648
DOI
10.3904/kjim.2018.272
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42694
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