Comparison of Serum PCSK9 Levels in Subjects with Normoglycemia, Impaired Fasting Glucose, and Impaired Glucose Tolerance

Authors
Eugene HanNan Hee ChoSeong-Su MoonHochan Cho
Department
Dept. of Internal Medicine (내과학); Institute for Cancer Research (암연구소)
Issue Date
2020
Citation
Endocrinology and Metabolism, Vol.35(2) : 480-483, 2020
ISSN
2093-5978
Abstract
We investigated proprotein convertase subtilisin/kexin type 9 (PCSK9) concentrations in individuals with normoglycemia, impaired fasting glucose (IFG), and impaired glucose tolerance (IGT). This was a pilot, cross-sectional study including 92 individuals who had not been diagnosed with or treated for diabetes. We measured PCSK9 levels in three groups of subjects; namely, normoglycemia (n=57), IFG (n=21), and IGT (n=14). Individuals with IFG and IGT showed higher PCSK9 concentrations than those in the normoglycemic group, with the highest serum PCSK9 concentrations found in individuals with IGT (55.25±15.29 ng/mL for normoglycemia, 63.47±17.78 ng/mL for IFG, 72.22±15.46 ng/mL for IGT, analysis of variance P=0.001). There were no significant differences in high- or low-density lipoprotein cholesterol among groups. Serum PCSK9 levels are increased in patients with prediabetes compared to subjects with normoglycemia.
Keywords
Pro-protein convertase subtilisin-kexin type 9Prediabetic stateGlucose intoleranceGlucose tolerance testMetabolic syndrome
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/42754
Appears in Collections:
1. Journal Papers (연구논문) > 1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. Journal Papers (연구논문) > 3. Research Institutues (연구소) > Institute for Cancer Research (암연구소)
Keimyung Author(s)
한유진; 조난희; 조호찬
Full Text
https://e-enm.org/journal/view.php?number=2054
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