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Regulation of Adipsin Expression by Endoplasmic Reticulum Stress in Adipocytes

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Affiliated Author(s)
박재형조호찬
Alternative Author(s)
Park, Jae HyungCho, Ho Chan
Journal Title
Biomolecules
ISSN
2218-273X
Issued Date
2020
Keyword
adipsinendoplasmic reticulum stressadipocytesobesitydiabetes mellitus
Abstract
Adpsin is an adipokine that stimulates insulin secretion from β-cells and improves glucose tolerance. Its expression has been found to be markedly reduced in obese animals. However, it remains unclear what factors lead to downregulation of adipsin in the context of obesity. Endoplasmic reticulum (ER) stress response is activated in various tissues under obesity-related conditions and can induce transcriptional reprogramming. Therefore, we aimed to investigate the relationship between adipsin expression and ER stress in adipose tissues during obesity. We observed that obese mice exhibited decreased levels of adipsin in adipose tissues and serum and increased ER stress markers in adipose tissues compared to lean mice. We also found that ER stress suppressed adipsin expression via adipocytes-intrinsic mechanisms. Moreover, the ER stress-mediated downregulation of adipsin was at least partially attributed to decreased expression of peroxisome proliferator-activated receptor γ (PPARγ), a key transcription factor in the regulation of adipocyte function. Finally, treatment with chemical chaperones recovered the ER stress-mediated downregulation of adipsin and PPARγ in vivo and in vitro. Our findings suggest that activated ER stress in adipose tissues is an important cause of the suppression of adipsin expression in the context of obesity.
Department
Dept. of Physiology (생리학)
Dept. of Internal Medicine (내과학)
Publisher
School of Medicine (의과대학)
Citation
Ka-Young Ryu et al. (2020). Regulation of Adipsin Expression by Endoplasmic Reticulum Stress in Adipocytes. Biomolecules, 10(2), 314. doi: 10.3390/biom10020314
Type
Article
ISSN
2218-273X
DOI
10.3390/biom10020314
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/42967
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Physiology (생리학)
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