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Clinicopathological Characteristics of PIK3CA Mutation and Amplification in Korean Patients with Breast Cancers

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Affiliated Author(s)
이무현조지형권선영이재호
Alternative Author(s)
Lee, Moo HyunCho, Ji HyoungKwon, Sun YoungLee, Jae Ho
Journal Title
International Journal of Medical Sciences
ISSN
1449-1907
Issued Date
2020
Keyword
breast carcinomaPIK3CA mutationPIK3CA amplification
Abstract
The frequency of PIK3CA mutation and amplification was various and their clinical significances have not been clarified in Korean patients with invasive breast carcinoma (IBC). The study aimed to investigate the clinical and prognostic significances of PIK3CA mutation and amplification in IBC patients. DNA was isolated from paired normal and tumoral tissues in 128 IBC patients and the mutation and expression of PIK3CA gene were analyzed. PIK3CA mutation and expression was detected in 14.3% and 21.9% of IBC patients, respectively. And the level of PIK3CA expression was not different according to the presence of PIK3CA mutation (p = 0.775). PIK3CA mutation and expression were significantly associated with Luminal A type (p = 0.017 and p = 0.011, respectively). However, they did not have any clinical and prognostic values for IBC patients. This result suggested that alterations of PIK3CA pathway contribute to the pathogenesis of specific type of IBC.
Department
Dept. of Surgery (외과학)
Dept. of Pathology (병리학)
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Moo-Hyun Lee. (2020). Clinicopathological Characteristics of PIK3CA Mutation and Amplification in Korean Patients with Breast Cancers. International Journal of Medical Sciences, 17(8), 1131-1135. doi: 10.7150/ijms.44319
Type
Article
DOI
10.7150/ijms.44319
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43114
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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