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NAA10 as a New Prognostic Marker for Cancer Progression

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Author(s)
하은영김진영조치흠신소진서지혜
Alternative Author(s)
Ha, Eun YoungKim, Jin YoungCho, Chi HeumShin, So JinSeo, Ji Hye
Issued Date
2020
Keyword
acetyltransferasebiomarkercancer prognosisNAA10
Abstract
N-α-acetyltransferase 10 (NAA10) is an acetyltransferase that acetylates both N-terminal amino acid and internal lysine residues of proteins. NAA10 is a crucial player to regulate cell proliferation, migration, differentiation, apoptosis, and autophagy. Recently, mounting evidence presented the overexpression of NAA10 in various types of cancer, including liver, bone, lung, breast, colon, and prostate cancers, and demonstrated a correlation of overexpressed NAA10 with vascular invasion and metastasis, thereby affecting overall survival rates of cancer patients and recurrence of diseases. This evidence all points NAA10 toward a promising biomarker for cancer prognosis. Here we summarize the current knowledge regarding the biological functions of NAA10 in cancer progression and provide the potential usage of NAA10 as a prognostic marker for cancer progression.
Department
Dept. of Biochemistry (생화학)
Dept. of Internal Medicine (내과학)
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine (의과대학)
Citation
Sun Myung Kim. (2020). NAA10 as a New Prognostic Marker for Cancer Progression. International Journal of Molecular Sciences, 21(21), 8010-. doi: 10.3390/ijms21218010
Type
Article
ISSN
1422-0067
DOI
10.3390/ijms21218010
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43116
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
1. School of Medicine (의과대학) > Dept. of Internal Medicine (내과학)
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
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