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Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries

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Affiliated Author(s)
강구정
Alternative Author(s)
Kang, Koo Jeong
Journal Title
Journal of clinical medicine
ISSN
2077-0383
Issued Date
2020
Keyword
pediatric liver transplantationsurvivalgraft survivalcomplication
Abstract
Background:
This retrospective study aimed to evaluate overall survival and the risk factors for mortality among Korean pediatric liver transplantation (LT) patients using data from two national registries: the Korean Network Organ Sharing (KONOS) of the Korea Centers for Disease Control and Prevention and the Korean Organ Transplantation Registry (KOTRY).

Methods:
Prospectively collected data of 755 pediatric patients who underwent primary LT (KONOS, February 2000 to December 2015; KOTRY, May 2014 to December 2017) were retrospectively reviewed.

Results:
The 1-, 5-, 10-, and 15-year survival rates were 90.6%, 86.7%, 85.8%, and 85.5%, respectively, in KONOS, and the 1-month, 3-month, 1-year, and 2-year survival rates were 92.1%, 89.4%, 89.4%, and 87.2%, respectively, in KOTRY. There was no significant difference in survival between the two registries. Multivariate analysis identified that body weight ≥6 kg (p <0.001), biliary atresia as underlying liver disease (p = 0.001), and high-volume center (p < 0.001) were associated with better survival according to the KONOS database, while hepatic artery complication (p < 0.001) was associated with poorer overall survival rates according to the KOTRY database.

Conclusion:
Long-term pediatric patient survival after LT was satisfactory in this Korean national registry analysis. However, children with risk factors for poor outcomes should be carefully managed after LT.
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Suk Kyun Hong et al. (2020). Outcomes of Pediatric Liver Transplantation in Korea Using Two National Registries. Journal of clinical medicine, 9(11), 3435–3448. doi: 10.3390/jcm9113435
Type
Article
ISSN
2077-0383
DOI
10.3390/jcm9113435
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43150
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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