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Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis

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Affiliated Author(s)
이혜원
Alternative Author(s)
Lee, Hye Won
Journal Title
Life
ISSN
2075-1729
Issued Date
2020
Keyword
biomarkerliver fibrosislong noncoding RNA LeXisnon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisuntranslated RNA.
Abstract
Non-invasive diagnostic markers are needed to ease the diagnosis of non-alcoholic steatohepatitis (NASH) among patients with non-alcoholic fatty liver disease (NAFLD). The long noncoding RNA (lncRNA) LeXis is related to cholesterol metabolism and hepatic steatosis in mice, and its batch genome conversion in humans is TCONS_00016452. Here, we aimed to evaluate the potential of lncRNA LeXis as a non-invasive diagnostic marker for NASH. We analyzed a total of 44 NAFLD patients whose diagnosis was confirmed by a pathologist through analysis of a percutaneous liver biopsy. The expression of LeXis in the plasma of NAFLD patients with and without NASH was compared using quantitative real-time polymerase chain reaction. The expression of plasma LeXis was significantly higher in patients with NASH than in those with NAFL (8.2 (5.0-14.9); 4.6 (4.0-6.6), p = 0.025). The area under the receiver operating characteristic curve was 0.743 (95% CI 0.590-0.895, p < 0.001), and a sensitivity of 54.3% and specificity of 100% could be achieved for NASH diagnosis. Low LeXis was independently associated with NASH diagnosis in patients with NAFLD (p = 0.0349, odds ratio = 22.19 (5% CI, 1.25-395.22)). Therefore, circulating lncRNA LeXis could be a potential non-invasive diagnostic biomarker for NASH.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine (의과대학)
Citation
Jung Gil Park et al. (2020). Plasma Long Noncoding RNA LeXis is a Potential Diagnostic Marker for Non-Alcoholic Steatohepatitis. Life, 10(10), 230. doi: 10.3390/life10100230
Type
Article
ISSN
2075-1729
DOI
10.3390/life10100230
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43232
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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