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Pinealectomy increases thermogenesis and decreases lipogenesis

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Author(s)
문교철서지혜하은영
Alternative Author(s)
Mun, Kyo CheolSeo, Ji HyeHa, Eun Young
Issued Date
2020
Keyword
pinealectomymelatoninbrown adipose tissuethermogenesislipogenesis
Abstract
The present study was designed to determine the effects of pineal gland‑derived melatonin on obesity by employing a rat pinealectomy (Pnx) model. After 10 weeks of a high‑fat diet, rats received sham or Pnx surgery followed by a normal chow diet for 10 weeks. Reverse transcription‑quantitative PCR, western blotting analysis, immunohistochemistry and ELISA were used to determine the effects of Pnx. Pnx decreased the expression of melatonin receptor (MTNR)1A and MTNR1B, in brown adipose tissues (BAT) and white adipose tissues (WAT). Pnx rats showed increased insulin sensitivity compared with those that received sham surgery. Leptin levels were significantly decreased in the serum of the Pnx group. In addition, Pnx stimulated thermogenic genes in BAT and attenuated lipogenic genes in both WAT and the liver. Histological analyses revealed a marked decrease in the size of lipid droplets and increased expression of uncoupling protein 1 in BAT. In the liver of the Pnx group, the size and number of lipid droplets had also decreased. In conclusion, the results presented in the current study suggested that Pnx increases thermogenesis in BAT and decreases lipogenesis in WAT and the liver.
Department
Dept. of Biochemistry (생화학)
Publisher
School of Medicine (의과대학)
Citation
Mikyung Kim. (2020). Pinealectomy increases thermogenesis and decreases lipogenesis. Molecular medicine reports, 22(5), 4289-4297. doi: 10.3892/mmr.2020.11534
Type
Article
ISSN
1791-3004
DOI
10.3892/mmr.2020.11534
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43247
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Biochemistry (생화학)
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