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In vivo modeling of metastatic human high-grade serous ovarian cancer in mice

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Affiliated Author(s)
권선영조치흠
Alternative Author(s)
Kwon, Sun YoungCho, Chi Heum
Journal Title
PLoS Genetics
ISSN
1553-7404
Issued Date
2020
Abstract
Metastasis is responsible for 90% of human cancer mortality, yet it remains a challenge to model human cancer metastasis in vivo. Here we describe mouse models of high-grade serous ovarian cancer, also known as high-grade serous carcinoma (HGSC), the most common and deadliest human ovarian cancer type. Mice genetically engineered to harbor Dicer1 and Pten inactivation and mutant p53 robustly replicate the peritoneal metastases of human HGSC with complete penetrance. Arising from the fallopian tube, tumors spread to the ovary and metastasize throughout the pelvic and peritoneal cavities, invariably inducing hemorrhagic ascites. Widespread and abundant peritoneal metastases ultimately cause mouse deaths (100%). Besides the phenotypic and histopathological similarities, mouse HGSCs also display marked chromosomal instability, impaired DNA repair, and chemosensitivity. Faithfully recapitulating the clinical metastases as well as molecular and genomic features of human HGSC, this murine model will be valuable for elucidating the mechanisms underlying the development and progression of metastatic ovarian cancer and also for evaluating potential therapies.
Department
Dept. of Pathology (병리학)
Dept. of Obstetrics & Gynecology (산부인과학)
Publisher
School of Medicine (의과대학)
Citation
Olga Kim et al. (2020). In vivo modeling of metastatic human high-grade serous ovarian cancer in mice. PLoS Genetics, 16(6), e1008808. doi: 10.1371/journal.pgen.1008808
Type
Article
ISSN
1553-7404
DOI
10.1371/journal.pgen.1008808
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43273
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Obstetrics & Gynecology (산부인과학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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