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Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers

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Affiliated Author(s)
이윤한김신이재호
Alternative Author(s)
Lee, Yun HanKim, ShinLee, Jae Ho
Journal Title
OncoTargets and Therapy
ISSN
1178-6930
Issued Date
2020
Keyword
TZAPtelomerecolorectal cancerZBTB48
Abstract
Purpose:
The zinc finger protein, ZBTB48, is a telomere-associated protein. It was renamed as telomeric zinc finger-associated protein (TZAP) binding to elongated telomeres. However, its expression level was not measured in cancers.

Patients and Methods:
We analyzed TZAP mRNA levels in 60 colorectal cancers (CRC) and its correlation with telomere length and TERT was studied.

Results:
TZAP mRNA in CRC was higher statistically than that in paired non-cancerous tissues (p = 0.033). Higher TZAP was found in carcinoembryonic antigen (CEA)-positive CRCs (> 5 ng/mL) (p = 0.012). Shorter telomere was found in CRCs with high TZAP expression than that with low TZAP expression (p = 0.010). According to quantitative correlation analysis, TZAP has a correlation with age (r = − 0.349, p = 0.007), TERT (r = 0.279, p = 0.041) and telomere length (r = − 0.305, p = 0.021). TZAP expression did not harbor prognostic value in CRC. Inhibition of TZAP expression by siRNA suppresses cell growth in HT29 cells; however, it resulted in increased cell viability in HCT116 cells. TZAP inhibition induces a decrease in mRNA levels of TERT in both HT29 and HCT116 cells. TCGA data analysis showed higher expression of TZAP showed poorer overall survival in colon cancer (p = 0.001); however, it did not have a significance in rectal cancer (p = 0.951).

Conclusion:
We suggested that TZAP may be a possible biomarker for CRC.
Department
Dept. of Molecular Medicine (분자의학)
Dept. of Immunology (면역학)
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Soo-Jung Jung. (2020). Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers. OncoTargets and Therapy, 13, 12933-12942. doi: 10.2147/OTT.S274394
Type
Article
DOI
10.2147/OTT.S274394
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43476
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Immunology (면역학)
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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