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Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea

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Affiliated Author(s)
장효정
Alternative Author(s)
Jang, Hyo Jeong
Journal Title
Journal of Korean Medical Science
ISSN
1598--6357
Issued Date
2021
Keyword
Non-alcoholic Fatty Liver DiseaseSubclinical HypothyroidismLiver SteatosisLiver Fibrosis
Abstract
Background:
It is uncertain whether non-alcoholic fatty liver disease (NAFLD) is associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and related factors of SH in pediatric patients with NAFLD. We also evaluate the association between liver fibrosis and SH.

Methods:
We retrospectively reviewed medical records for patients aged 4 to 18 years who were diagnosed with NAFLD and tested for thyroid function from January 2015 to December 2019 at 10 hospitals in Korea.

Results:
The study included 428 patients with NAFLD. The prevalence of SH in pediatric NAFLD patients was 13.6%. In multivariate logistic regression, higher levels of steatosis on ultrasound and higher aspartate aminotransferase to platelet count ratio index (APRI) score were associated with increased risk of SH. Using receiver operating characteristic curves, the optimal cutoff value of the APRI score for predicting SH was 0.6012 (area under the curve, 0.67; P < 0.001; sensitivity 72.4%, specificity 61.9%, positive predictive value 23%, and negative predictive value 93.5%).

Conclusion:
SH was often observed in patients with NAFLD, more frequently in patients with more severe liver damage. Thyroid function tests should be performed on pediatric NAFLD patients, especially those with higher grades of liver steatosis and fibrosis.
Department
Dept. of Pediatrics (소아청소년학)
Publisher
School of Medicine (의과대학)
Citation
So Yoon Choi et al. (2021). Severe Phenotype of Non-alcoholic Fatty Liver Disease in Pediatric Patients with Subclinical Hypothyroidism: a Retrospective Multicenter Study from Korea. Journal of Korean Medical Science, 36(20), e137. doi: 10.3346/jkms.2021.36.e137
Type
Article
ISSN
1598--6357
DOI
10.3346/jkms.2021.36.e137
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43509
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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