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Early-Phase SPECT/CT for Diagnosing Osteomyelitis: A Retrospective Pilot Study

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Affiliated Author(s)
원경숙
Alternative Author(s)
Won, Kyoung Sook
Journal Title
Korean Journal of Radiology
ISSN
2005--8330
Issued Date
2021
Keyword
Bone and bonesRadionuclide imagingSingle photon emission computed tomography computed tomography
Abstract
Objective:
The aim of this pilot study was to investigate the potential of early-phase single-photon emission computed tomography (SPECT)/computed tomography (CT) using technetium-99m methyl diphosphonate (99mTc-MDP) for diagnosing osteomyelitis (OM).

Materials and Methods:
Twenty-one patients with suspected OM were enrolled retrospectively. Three-phase bone scan (TPBS), early-phase SPECT/CT (immediately after blood pool planar imaging), and delayed-phase SPECT/CT (immediately after delayed planar imaging) were performed. The final diagnoses were established through surgery or clinical follow-up for over 6 months. We compared three diagnostic criteria based on (I) TPBS alone, (II) combined TPBS and delayed-phase SPECT/CT, and (III) early-phase SPECT/CT alone.

Results:
OM was diagnosed in 11 of 21 patients (nine surgically and two clinically). Of the 11 OM patients, criterion-I, criterion-II, and criterion-III were positive in six, seven, and 10 patients, respectively. Of the 10 non-OM patients, criterion-I, criterion-II, and criterion-III were negative in five, five, and seven patients, respectively. The sensitivity/specificity/accuracy of criterion-I, criterion-II, and criterion-III for diagnosing OM were 54.5%/50.0%/55.0%, 63.6%/50.0%/57.1%, and 90.9%/70.0%/87.5%, respectively.

Conclusion:
This pilot study demonstrated the potential of using the early-phase SPECT/CT to diagnose OM. Based on the results, prospective studies with a larger sample size should be conducted to confirm the efficacy of early-phase SPECT/CT.
Department
Dept. of Nuclear Medicine (핵의학)
Publisher
School of Medicine (의과대학)
Citation
Soo Jin Lee et al. (2021). Early-Phase SPECT/CT for Diagnosing Osteomyelitis: A Retrospective Pilot Study. Korean Journal of Radiology, 22(4), 604–611. doi: 10.3348/kjr.2019.0746
Type
Article
ISSN
2005--8330
DOI
10.3348/kjr.2019.0746
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43513
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학)
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