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신경퇴행성 질환이 암 발병에 미치는 영향: 국민건강보험공단 빅데이터를 이용한 코호트 연구

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Affiliated Author(s)
김정범김양태이호준김희철
Alternative Author(s)
Kim, Jung BumKim, Yang TaeLee, Ho JunKim, Hee Chul
Journal Title
노인정신의학
ISSN
2733--4600
Issued Date
2021
Keyword
Cohort studyNeurodegenerative diseasesAlzheimer's diseaseParkinson's diseasePick diseaseCancer
Abstract
Objective:
We evaluated the association between cancer and various neurodegenerative diseases (NDs), including Alzheimer's disease (AD), Parkinson's disease (PD), and circumscribed brain atrophy (CBA) and to evaluate the impact of ND on the development of cancer.

Methods: A population-based longitudinal study was conducted using the National Health Information Database for 2002-2015. A total of 9,365 ND patients (3,157 AD, 5,866 PD, 342 CBA) were included in the study, as were 46,818 matched controls.

Results:
Various NDs were newly developed in control and ND groups during the 10-year follow-up periods. Newly developed ND cases were as follows: 33.0% in control, 35.3% in AD, 19.9% in PD, and 45.3% in CBA. Cancer developed in 22.6% of ND groups (20.5% AD, 23.6% PD, 24.3% CBA) and in 18.5% of control group. Cancer development was significantly higher in AD patients with new ND cases (especially PD cases), compared to patients without new ND cases (22.8% vs. 19.3%, p=0.019). There were no differences in the frequencies of cancer development between patients with and without new ND cases in PD, CBA, and control groups. The adjusted hazard ratios for cancer in AD, PD, and CBA groups were 1.43, 1.55, and 1.58, respectively.

Conclusion:
This study showed that various NDs are positively associated with development of cancer and suggests that newly developed PD in AD group during the follow-up period may influence the development of cancer that follows.
Department
Dept. of Psychiatry (정신건강의학)
Publisher
School of Medicine (의과대학)
Citation
So Yeon Lee et al. (2021). 신경퇴행성 질환이 암 발병에 미치는 영향: 국민건강보험공단 빅데이터를 이용한 코호트 연구. 노인정신의학, 25(1), 14–22. doi: 10.47825/jkgp.2021.25.1.14
Type
Article
ISSN
2733--4600
DOI
10.47825/jkgp.2021.25.1.14
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43520
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Psychiatry (정신건강의학)
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