계명대학교 의학도서관 Repository

No association between telomere length and osteonecrosis of the femoral head

Metadata Downloads
Affiliated Author(s)
이시욱이경재이재호
Alternative Author(s)
Lee, Si WookLee, Kyung JaeLee, Jae Ho
Journal Title
BMC Musculoskelet Disord
ISSN
1471-2474
Issued Date
2021
Keyword
Telomere lengthONFHOsteonecrosisErythrocyte sedimentation rateFemoral head
Abstract
Background:
Telemore length (TL) shortening has been found in many diseases. However, clinical characteristics of TL shortening in osteonecrosis of the femoral head (ONFH) has not been investigated. Therefore, we studied whether TL changes have clinicopathological values in ONFH.

Methods:
The TL in the synovial tissues of 36 ONFH and 127 control patients (femoral neck fracture) was examined by quantitative real-time PCR as relative length, Δ Ct value. In addition, the correlation between TL and clinical features of ONFH and controls was analyzed.

Results:
The average TL in the femoral tissues was 1.46 ± 3.12 (standard deviation). The average TL in the ONFH and control tissues was 1.92 ± 4.11 and 1.34 ± 2.78, respectively, however, the difference was absent (p = 0.324). Furthermore, a shorter TL was tended to be associated with erythrocyte sedimentation rate (100% vs. 61.5%, p = 0.073); however, the association was not statistically significant.

Conclusions:
In this study, we demonstrated that there is no association between the TL and clinicopathologic characteristics of ONFH patients. However, further studies considering the genetic factors are needed to be performed.
Department
Dept. of Orthopedic Surgery (정형외과학)
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Si-Wook Lee. (2021). No association between telomere length and osteonecrosis of the femoral head. BMC Musculoskelet Disord, 22(1), 176-. doi: 10.1186/s12891-021-04047-5
Type
Article
DOI
10.1186/s12891-021-04047-5
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43576
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학)
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.