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Clinical implications of thrombocytosis in acute phase Kawasaki disease

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Affiliated Author(s)
박재희최희정
Alternative Author(s)
Choi, Hee Joung
Journal Title
Eur J Pediatr
ISSN
1432-1076
Issued Date
2021
Keyword
Kawasaki diseaseThrombocytosisOutcomePediatric
Abstract
In Kawasaki disease (KD), thrombocytosis is commonly found in the subacute phase. However, the exact significance of thrombocytosis in the acute phase of KD is unclear. To evaluate serum platelet counts in patients during the acute phase of KD and assess the clinical outcomes according to the degree of thrombocytosis, we collected data of KD patients between 2009 and 2017. A total of 505 patients with KD were enrolled, and 249 (49.3%) patients had thrombocytosis, including mild (69.5%), moderate (21.7%), severe (4.8%), and extreme (4.0%) thrombocytosis. Correlation analysis revealed a positive correlation between the maximum platelet count and admission duration (r = 0.359, p < 0.001) and fever duration (r = 0.204, p < 0.001). The maximum platelet count was significantly higher in IVIG non-responders than that in IVIG responders (629 ± 201 × 109/L vs. 499 ± 154 × 109/L, p < 0.001), and in patients with coronary artery dilatation (CAD) than in those without CAD (602 ± 201 × 109/L vs. 512 ± 164 × 109/L, p < 0.001).

Conclusion: Thrombocytosis in acute phase KD was associated with poor clinical outcomes such as IVIG non-responsiveness, CAD, and prolonged admission and fever durations.
Department
Dept. of Pediatrics (소아청소년학)
Publisher
School of Medicine (의과대학)
Citation
Jae Hui Park and Hee Joung Choi. (2021). Clinical implications of thrombocytosis in acute phase Kawasaki disease. Eur J Pediatr, 180, 1841–1846. doi: 10.1007/s00431-021-03966-8
Type
Article
ISSN
1432-1076
DOI
10.1007/s00431-021-03966-8
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43598
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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