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High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis

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Affiliated Author(s)
신형찬
Alternative Author(s)
Shin, Hyeong Chan
Journal Title
Yeungnam Univ J Med
ISSN
2384-0293
Issued Date
2021
Keyword
CarcinomaMucoepidermoid carcinomaPrognosisThyroid gland
Abstract
Mucoepidermoid carcinoma (MEC) is the most common malignant neoplasm of the salivary gland, but primary thyroid MEC has rarely been reported and usually has a good prognosis. Herein, I report a case of thyroidal MEC with a poor prognosis in an 82-year-old woman with an anterior neck mass. Ultrasonography and computed tomography revealed a thyroid mass. The patient initially underwent fine-needle aspiration, was diagnosed with malignancy, and underwent a right lobectomy. On gross examination, a 4.0×3.6×2.6 cm-sized ill-defined, unencapsulated, and infiltrative tan to whitish mass with necrosis was identified. Microscopically, epidermoid tumor cell nests or solid sheets were identified. Mucous cells that were positive for periodic acid–Schiff and mucicarmine stains were also identified within epidermoid cell nests. Frequent mitosis and necrosis were observed. Immunohistochemical staining for p40 and p63 was positive, and that for thyroid transcription factor-1 and paired box gene 8 was focally positive. According to the Armed Forces Institute of Pathology grading system for salivary gland MEC, the current case was classified as high-grade MEC. After surgery, the patient suffered from dyspnea due to a remnant neck mass that compressed and obstructed the trachea; therefore, the patient refused further treatment. Thyroidal MECs are considered low-grade with a favorable prognosis, but there are several reported cases of thyroidal MEC with poor prognosis. The current case is a rare presentation of high-grade thyroidal MEC with a poor prognosis.
Department
Dept. of Pathology (병리학)
Publisher
School of Medicine (의과대학)
Citation
Hyeong Chan Shin. (2021). High-grade mucoepidermoid carcinoma in the thyroid gland with poor prognosis. Yeungnam Univ J Med, 38(2), 169–174. doi: 10.12701/yujm.2021.00941
Type
Article
ISSN
2384-0293
DOI
10.12701/yujm.2021.00941
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43722
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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