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Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression

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Affiliated Author(s)
이재호이윤한
Alternative Author(s)
Lee, Jae HoLee, Yun Han
Journal Title
Anticancer Res
ISSN
1791-7530
Issued Date
2021
Keyword
HCCCALM2calcium signalingE2F5cell cycletherapeutic target
Abstract
Background/Aim:
The aim of this study was to reveal the novel roles of calmodulin 2 (CALM2) in hepatocellular carcinoma (HCC) progression.

Materials and Methods:
The effects of knockdown of CALM2 expression by siRNA were investigated using various experimental approaches in both cellular and molecular levels.

Results:
Silencing of CALM2 inhibited HCC cell proliferation and colony formation through induction of apoptosis. At the molecular level, CALM2-specific knockdown led to the common dysregulation of 154 genes in HCC cells. Notably, E2F transcription factor 5 (E2F5), which is functionally associated with migration, invasion and proliferation, was generally down-regulated. These functional associations were confirmed in HCC clinical samples. Reflecting the molecular changes, CALM2 knockdown reduced the migration and invasion abilities of HCC cells and abrogated the potency of tumor formation in vivo.

Conclusion:
Targeting CALM2 may be a molecular strategy for both primary HCC treatment and prevention of metastasis or recurrence.
Department
Dept. of Anatomy (해부학)
Dept. of Molecular Medicine (분자의학)
Publisher
School of Medicine (의과대학)
Citation
SO-YOUNG PARK. (2021). Targeting CALM2 Inhibits Hepatocellular Carcinoma Growth and Metastasis by Suppressing E2F5-mediated Cell Cycle Progression. Anticancer Res, 41(3), 1315-1325. doi: 10.21873/anticanres.14889
Type
Article
DOI
10.21873/anticanres.14889
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43734
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Molecular Medicine (분자의학)
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