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Differences in the mitochondrial microsatellite instability of Keratoacanthoma and cutaneous squamous cell carcinoma

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Affiliated Author(s)
정혜라이재호김대광
Alternative Author(s)
Jung, Hye RaLee, Jae HoKim, Dae Kwang
Journal Title
Cancer Genet
ISSN
2210-7762
Issued Date
2021
Keyword
KeratoacanthomaSquamous cell carcinomaMitochondrial microsatellite instabilityD-loop regionDifferential diagnosis
Abstract
Keratoacanthoma (KA) is a common cutaneous neoplasm which often resembles typical squamous cell carcinoma (SCC) in both its clinical and historical presentation. Several studies have attempted to identify methods for distinguishing between KA and SCC, however, none of these have proven to play any obvious roles in these tumors. Given this we went on to evaluate mitochondrial microsatellite instability (mtMSI) in KA and SCC in an effort to understand these tumors better. DNA was isolated from paired normal and tumoral tissues donated by 57 KA patients and 43 SCC patients. MtMSI was then analyzed using eight microsatellite markers and was observed in 2 (3.5%) of the 57 KA patients and 8 (18.6%) of the 43 SCC patients, respectively. MtMSI was also shown to affect different locations depending on tumor type. In KA patients, mtMSI was detected at mitochondrial D514 D-loop and presented with (CA) n repeats, in contrast, all of the SCC patient experienced mtMSI at the D310 with (C)n repeats of the D-loop region. These differences in location were found to be significant, which may support the hypothesis that KA and SCC have different pathogenetic pathways. Our results also suggest that mtMSI may be a candidate for developing novel differential diagnostic methods for KA and SCC.
Department
Dept. of Pathology (병리학)
Dept. of Anatomy (해부학)
Dept. of Medical Genetics (의학유전학)
Publisher
School of Medicine (의과대학)
Citation
Mohammad Rizwan Alam. (2021). Differences in the mitochondrial microsatellite instability of Keratoacanthoma and cutaneous squamous cell carcinoma. Cancer Genet, 256 115-121. doi: 10.1016/j.cancergen.2021.05.005
Type
Article
DOI
10.1016/j.cancergen.2021.05.005
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/43782
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
1. School of Medicine (의과대학) > Dept. of Medical Genetics (의학유전학)
1. School of Medicine (의과대학) > Dept. of Pathology (병리학)
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