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Risk factors for Takotsubo syndrome following cardiac surgery: A case-control study

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Affiliated Author(s)
김윤석
Alternative Author(s)
Kim, Yun Seok
Journal Title
J Card Surg
ISSN
1540-8191
Issued Date
2021
Keyword
cardiac surgerypostoperative managementTakotsubo syndrome
Abstract
Objective:
Takotsubo syndrome following cardiac surgery is a rare occurrence. However, early diagnosis is essential to prevent treatment which could increase the left ventricular outflow tract pressure gradient in patients with Takotsubo syndrome, and lead to cardiogenic shock. Therefore, our study aimed to identify the incidence of Takotsubo syndrome after cardiopulmonary bypass and the associated risk factors and prognosis.

Methods:
We retrospectively studied 5773 patients who underwent cardiopulmonary bypass between February 2007 and July 2017. Among these, Takotsubo syndrome was diagnosed in 52 (0.9%). To evaluate the risk factors for Takotsubo syndrome, 104 of the remaining 5721 patient were randomly selected as the control group (1:2 ratio). Univariate and multivariate logistic regression analyses were used for risk factor analysis.

Results:
Majority of patients (69.2%) in the Takotsubo syndrome group underwent mitral valve surgery, compared with 32.7% in the control group. The following risk factors of Takotsubo syndrome were identified: atrio-ventricular valve surgery (odds ratio (OR) 10.5; 95% confidence interval (CI), 2.6–42.5; p = 0.001); and the immediate postoperative use of epinephrine (OR, 3.3; 95% CI, 1.0–10.7; p = 0.05) and dobutamine (OR, 4.8; 95% CI, 1.72–13.3; p = 0.003). Hypertension was a significant protective factor against Takotsubo syndrome following cardiac surgery (OR, 0.22; 95% CI, 0.06–0.73; p = 0.01).

Conclusion:
Takotsubo syndrome following cardiac surgery is rare. Immediate postoperative use of epinephrine and doputamine, as well as atrio-ventricular valve surgery were factors associated with the development of Takotsubo syndrome.
Department
Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
Publisher
School of Medicine (의과대학)
Citation
Yun Seok Kim and Ju Yong Lim. (2021). Risk factors for Takotsubo syndrome following cardiac surgery: A case-control study. J Card Surg, 36(8), 2767–2773. doi: 10.1111/jocs.15626
Type
Article
ISSN
1540-8191
DOI
10.1111/jocs.15626
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43810
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Thoracic & Cardiovascular Surgery (흉부외과학)
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