계명대학교 의학도서관 Repository

Bariatric surgery versus medical therapy in Korean obese patients: prospective multicenter nonrandomized controlled trial (KOBESS trial)

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Affiliated Author(s)
류승완
Alternative Author(s)
Ryu, Seung Wan
Journal Title
Ann Surg Treat Res
ISSN
2288-6796
Issued Date
2021
Keyword
AsiaBariatric surgeryMetabolic diseasesObesity
Abstract
Purpose:
The aim of this study was to show that bariatric surgery (BS) is more effective than medical therapy (MT) in Asian obese patients.

Methods:
In this prospective, multicenter, nonrandomized, controlled trial, obese patients with body mass index of ≥35 kg/m2 or 30.0–34.9 kg/m2 with obesity-related comorbidities were assigned to undergo BS, such as laparoscopic sleeve gastrectomy and Roux-en-Y gastric bypass, or MT. Patients who underwent BS were evaluated 4, 12, 24, and 48 weeks after surgery, whereas patients who received MT were monitored at a hospital every 6 weeks for 1 year. At each visit, weight, waist and hip circumference, and blood pressure were measured, and patients underwent physical examination and laboratory testing. Health-related quality of life (HQOL) was investigated using Euro QOL-5 Dimension, Impact of Weight on Quality of Life questionnaire-Lite and Obesity-related Problems scale.

Results:
The study included 264 patients from 13 institutions; of these, 64 underwent BS and 200 received MT. Of the patients who underwent BS, 6.3% experienced early complications. Relative weight changes from baseline to 48 weeks were significantly greater in the BS than in the MT group (26.9% vs. 2.1%, P < 0.001), as were the rates of remission of diabetes (47.8% vs. 16.7%, P = 0.014), hypertension (60.0% vs. 26.1%, P < 0.001), and dyslipidemia (63.2% vs. 22.0%, P < 0.001). HQOL was better in the BS than in the MT group at 48 weeks.

Conclusion:
BS was safe and effective in Korean obese patients, with greater weight reduction, remission of comorbidities, and quality of life improvement than MT.
Department
Dept. of Surgery (외과학)
Publisher
School of Medicine (의과대학)
Citation
Do Joong Park et al. (2021). Bariatric surgery versus medical therapy in Korean obese patients: prospective multicenter nonrandomized controlled trial (KOBESS trial). Ann Surg Treat Res, 101(4), 197–205. doi: 10.4174/astr.2021.101.4.197
Type
Article
ISSN
2288-6796
DOI
10.4174/astr.2021.101.4.197
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43846
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Surgery (외과학)
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