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Protective Effects of Bee Venom-Derived Phospholipase A(2) against Cholestatic Liver Disease in Mice

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Affiliated Author(s)
장효정
Alternative Author(s)
Jang, Hyo Jeong
Journal Title
Biomedicines
ISSN
2227-9059
Issued Date
2021
Keyword
bee venomphospholipase A2cholestatic liver diseaseapoptosisinflammationfibrosis
Abstract
Hepatocyte apoptosis and inflammation play important roles in cholestatic liver diseases. Bee venom-derived secretory phospholipase A2 (bvPLA2) has been shown to ameliorate various inflammatory diseases. However, whether bvPLA2 has a therapeutic effect against cholestatic liver disease has not been evaluated. Therefore, we investigated the effects of bvPLA2 on cholestatic liver injury and fibrosis in a murine model of 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet feeding. The administration of bvPLA2 ameliorated liver damage, cholestasis, and fibrosis in DDC diet-fed mice, as assessed by serum biochemical tests and histological examinations. In addition, bvPLA2 reduced myofibroblast accumulation, concomitant with suppression of transforming growth factor-β signaling cascade. The administration of bvPLA2 inhibited hepatocyte apoptosis in DDC diet-fed mice as represented by a reduction in the number of cells stained with terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling and suppression of caspase-3 activation. Moreover, bvPLA2 reduced cytokine production along with the inhibition of the nuclear factor kappa-B pathway. The number of regulatory T-cells was increased by bvPLA2, while the number of other immune cells, including neutrophils, macrophages, and CD8+ T-cells, was decreased. Our data indicate that the administration of bvPLA2 ameliorates cholestatic liver injury and fibrosis by inhibiting hepatocyte apoptosis and inflammation.
Department
Dept. of Pediatrics (소아청소년학)
Publisher
School of Medicine (의과대학)
Citation
Jung-Yeon Kim et al. (2021). Protective Effects of Bee Venom-Derived Phospholipase A(2) against Cholestatic Liver Disease in Mice. Biomedicines, 9(8), 992. doi: 10.3390/biomedicines9080992
Type
Article
ISSN
2227-9059
DOI
10.3390/biomedicines9080992
URI
https://kumel.medlib.dsmc.or.kr/handle/2015.oak/43930
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Pediatrics (소아청소년학)
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