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Polo-like kinase 4 as a potential predictive biomarker of chemoradioresistance in locally advanced rectal cancer

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Affiliated Author(s)
배성욱변상준김신이재호황일선권선영이혜원
Alternative Author(s)
Bae, Sung UkByun, Sang JunKim, ShinLee, Jae HoHwang, Il SeonKwon, Sun YoungLee, Hye Won
Journal Title
J Pathol Transl Med
ISSN
2383-7845
Issued Date
2022
Keyword
Polo-like kinase 4Rectal neoplasmsChemoradiotherapyBiomarker
Abstract
Background:
Polo-like kinase 4 (PLK4) is a serine/threonine protein kinase located in the centriole of the chromosome during the cell cycle. PLK4 overexpression has been described in a variety of many common human epithelial tumors. Conversely, PLK4 acts as a haploinsufficient tumor suppressor in some situations, highlighting the importance of strict regulation of PLK4 expression, activity, and function. Meanwhile, the importance of chemoradiation resistance in rectal cancer is being emphasized more than ever. We aimed to analyze PLK4 expression and the tumor regression grade (TRG) in patients with rectal cancer, treated with chemoradiotherapy (CRT).

Methods:
A retrospective study was conducted on 102 patients with rectal cancer who received preoperative CRT. Immunohistochemistry for PLK4 in paraffin-embedded tissue was performed from the biopsy and surgical specimens.

Results:
We found significant association between high expression of PLK4 and poor response to neoadjuvant CRT (according to both Mandard and The Korean Society of Pathologists TRG systems) in the pre-CRT specimens. Other clinicopathologic parameters did not reveal any correlation with PLK4 expression.

Conclusions:
This study revealed an association between high expression of PLK4 in the pre-CRT specimens and TRG. Our results indicated that PLK4 could potentially be a new predictor for CRT effect in patients with rectal cancer.
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