계명대학교 의학도서관 Repository

Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung

Metadata Downloads
Affiliated Author(s)
이재호
Alternative Author(s)
Lee, Jae Ho
Journal Title
Medicina (Kaunas)
ISSN
1648-9144
Issued Date
2021
Keyword
TZAPtelomerelung cancerZBTB48
Abstract
Background and Objectives:
Telomeric zinc finger-associated protein (TZAP) is a telomere regulation protein, previously known as ZBTB48. It binds preferentially to elongated telomeres, competing with telomeric repeat factors 1 and 2. TZAP expression may be associated with carcinogenesis, however; this study has not yet been performed in lung cancer. In this study, we examined the clinicopathological and prognostic values of TZAP expression in non-small cell lung cancer (NSCLC).

Materials and Methods: 
Data were collected from The Cancer Genome Atlas. The clinical and prognostic values of TZAP for NSCLC were examined in adenocarcinoma (AD) and squamous cell carcinoma (SCC).

Results: 
TZAP expression significantly increased in NSCLC tissues compared with normal tissues. In AD, TZAP expression was lower in patients with higher T stage (p = 0.005), and was associated with lymph node stage in SCC (p = 0.005). Survival analysis showed shorter disease-free survival in AD patients with lower TZAP expression (p = 0.047). TZAP expression did not have other clinical or prognostic value for AD and SCC.

Conclusions:
TZAP expression is a potential prognostic marker for NSCLC, especially in patients with AD.
Department
Dept. of Anatomy (해부학)
Publisher
School of Medicine (의과대학)
Citation
Gun-Jik Kim. (2021). Prognostic Value of Telomeric Zinc Finger-Associated Protein Expression in Adenocarcinoma and Squamous Cell Carcinoma of Lung. Medicina (Kaunas), 57(11), 1223 10.3390/medicina57111223
Type
Article
DOI
10.3390/medicina57111223
URI
http://kumel.medlib.dsmc.or.kr/handle/2015.oak/44143
Appears in Collections:
1. School of Medicine (의과대학) > Dept. of Anatomy (해부학)
Authorize & License
  • AuthorizeOpen
Files in This Item:

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.