Robust response of pulmonary pleomorphic carcinoma to pembrolizumab and sequential radiotherapy: A case report
- Affiliated Author(s)
- 박선효; 황일선; 김진희
- Alternative Author(s)
- Park, Sun Hyo; Hwang, Il Seon; Kim, Jin Hee
- Journal Title
- Respirol Case Rep
- ISSN
- 2051-3380
- Issued Date
- 2021
- Keyword
- PD-L1; pembrolizumab; pulmonary pleomorphic carcinoma
- Abstract
- Pulmonary pleomorphic carcinoma (PPC) is a rare type of non-small cell lung cancer (NSCLC) with a more aggressive clinical course and a worse outcome than other types of NSCLC. Pembrolizumab, a monoclonal antibody targeting programmed cell death-1 (PD-1), has been approved as the first-line treatment for advanced NSCLC with robust PD-L1 expression in at least 50% of tumour cells, without epidermal growth factor receptor gene (EGFR) mutations or anaplastic lymphoma kinase gene (ALK) rearrangement. Here, we report the case of an 81-year-old man with multiple comorbidities who was diagnosed with PPC and showed a robust response to pembrolizumab followed by radiation therapy without adverse effects. In the absence of randomized clinical trials for PPCs, our case report demonstrates the potential application of pembrolizumab and radiation therapy for the treatment of PPCs.
- 공개 및 라이선스
-
- 파일 목록
-
Items in Repository are protected by copyright, with all rights reserved, unless otherwise indicated.