손발톱 건선

Abstract

Chronic plaque psoriasis is the common disease of inflammatory nail disease. Ninety % of psoriasis patients experience nail symptom during the lifetime. Nail psoriasis is strongly associated with severe cutaneous psoriasis and psoriasis arthritis. Nail psoriasis patients experience pain, dysfunction, and social stigma and are subject to significant restrictions on their daily activities and quality of life. Psoriatic nail involving matrix can cause pitting, leukonychia, red spots in lunula, and nail plate crumbling, while nail bed involvement can result in onycholysis, “oil drop” discoloration, nail bed hyperkeratosis, and splinter hemorrhages. Evaluating the severity of nail disease can be challenging even in clinical practice. Although the nail psoriasis severity index (NAPSI) is widely used in clinical practice, it is time consuming and rarely used in clinical practice, so it is necessary to develop a simplified disease severity score for nail psoriasis. Treatment of nail psoriasis differs depending on the number of involved nails, the affected site of nail and presence of skin and/or joint involvement. Patients with mild nail psoriasis can be treated by topical therapy, and systemic treatment including biologic agents can be performed for severe nail psoriasis. Here, we aim to review the characteristics of nail psoriasis and provide an updated up-to-date review of the management and treatment options currently available for nail psoriasis.