https://kumel.medlib.dsmc.or.kr/handle/2015.oak/838 2026-04-04T17:47:40Z 2026-04-04T17:47:40Z 윤상미 이홍석 박근규 전동석 송홍석 https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15180 2023-01-26T18:08:33Z 1998-12-31T15:00:00Z

Title: B형 전림프구성 백혈병 1례 Author(s): 윤상미; 이홍석; 박근규; 전동석; 송홍석 Abstract: Prolymphocytic leukemia(PLL) first described by Galton and colleagues in 1974, is a distinct clinicopathologic variant of chronic lymphocytic leukemia. It is characterized by marked lymphocytosis, massive splenomegaly, minimal lymphadenopathy, and poor prognosis. The clinical course of PLL is generally brief, the median survival in Galton's original series was 4 months. We experienced a case of B-prolymphocytic leukemia. The patient was a 64 year-old man who presented with splenomegaly, marked leukocytosis and 65% of characteristic prolymphocytes in the peripheral blood. We report a case of PLL with a prolonged course after combination chemotherapy with daunorubicin, L-asparaginase, vincristine, prednisolone, and methotrexate.

1998-12-31T15:00:00Z 이홍석 송홍석 장용석 박근규 전동석 https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15179 2023-01-26T18:08:33Z 1998-12-31T15:00:00Z

Title: 만성 호중구성 백혈병 1례 Author(s): 이홍석; 송홍석; 장용석; 박근규; 전동석 Abstract: Chronic neutrophilic leukemia is a very rare myeloproliferative disorder of uncertain pathogenesis characterized by persistent neutrophilia without identifiable cause. Additionally chronic neutrophilic leukemia is characterized by hepatosplenomegaly, elevated leukocyte alkaline phosphatase, increased serum uric acid, bone marrow granulocyte hyperplasia, and the absence of philadephia chromosome. Recently we have experienced a case of neutrophilic leukemia in a 55 years old woman. On admission, peripheral blood leukocyte count was 94.000/㎕ and consist of 92% neutrophils. Many neutrophils had toxic granules, vacuoles and Dohle bodies. The underlying disease for leukemoid reaction had not been detected. Leukocyte alkaline phosphatase score was elevated. The bone marrow smear showed myeloid hyperplasia. The cytogenetic study shows normal bone marrow cell karyotype without philadelphia chromosome. The patient died after 13 months from the treatment with hydrxoyurea and intermittent transfusion.

1998-12-31T15:00:00Z 신동우 이인규 류성열 권기민 황준영 이상준 https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15178 2023-01-26T18:08:33Z 1998-12-31T15:00:00Z

Title: 갑상선 호르몬의 자가항체에 의한 갑상선 호르몬(T3)의 비정상적인 상승의 1례 Author(s): 신동우; 이인규; 류성열; 권기민; 황준영; 이상준 Abstract: Anti-thyroid hormone autoantibodies were reported in the Hashimoto's thyroiditis, Graves' disease, thyroid cancer and other thyroid diseases. Most of these autoantibodies are IgG. Immunologically, the thyroid hormone can be considered hapten and as such are unable to induced antibody production. But thyroid hormone can present to the immune system when this hapten is coupled with carrier protein such as thyroglobulin. Anti-thyroid hormone autoantibodies in serum will give falsely high or low thyroid hormone values in radioimmunossays. When the methods based upon absorption of free thyroid hormone or precipitation of all hormone-antibody complex are used, low values in favor of hypothyroidism will be found, whereas high values will be obtained with double-antibody of solid-phase technics. When these autoantibodies bind with thyriod hormone, abnormal elevation or decreased titers of thyroid hormone is seen in radiommunoassay. The interference gives clinicians inappropriate information about the patient's thyroid status. As a result, patients may receive unnecessary treatment from physicians who are unaware of the presence of the autoantibody. We report a case of abnormal elevation of T3 and TSH by anti-T3 autoantibodies in the serum of hypothyroid patient with Hashimoto's thyroiditis.

1998-12-31T15:00:00Z 안병훈 김중강 안재현 https://kumel.medlib.dsmc.or.kr/handle/2015.oak/15177 2023-01-26T18:08:32Z 1998-12-31T15:00:00Z

Title: 유양동에 발생한 거대 콜레스테롤 육아종성 낭종 치험 1례 Author(s): 안병훈; 김중강; 안재현 Abstract: Cholesterol granuloma is a rare lesion of the temporal bone and must be distinguished from epidermoid, cholesteatoma and other mass lesion of the temporal bone. We report a case of a 34-year-old female who presented to our institution with left temporal headache with bloody otorrhea. Bony destructive lesion of posterior cranial fossa was shown in computed tomography. The cystic mass was found and completely excised by transmastoid approach. At operation, cystic fluid was found in the lesion and sent to laboratory for cytologic evaluation. The fluid was remarkable for numerous inflammatory cells, blood breakdown products, multinucleated giant cells and cholesterol crystals and squamous epithelial cells, fibrous connective tissue and glandular tissue was present. Postoperative condition of the patient was good and discharged in postoperative 9 days without any complications. The patients has been receiving treatment for the last 5 months on an out patient basis without recurrence. The authors report a case of cholesterol granuloma cyst which was developed on mastoid the first time without any previous history of surgery. The differential diagnosis and radiologic evaluation are discussed.

1998-12-31T15:00:00Z